--- title: "Integrated bioreactor platform for rapid scale-up and translation" ocid: "ocds-b5fd17-11896b9a-3ab9-452a-b23c-b2855106b915" canonical_url: "https://d3tenders.com/contract/?ocid=ocds-b5fd17-11896b9a-3ab9-452a-b23c-b2855106b915" markdown_url: "https://d3tenders.com/contract/ocds-b5fd17-11896b9a-3ab9-452a-b23c-b2855106b915.md" json_url: "https://d3tenders.com/contract/ocds-b5fd17-11896b9a-3ab9-452a-b23c-b2855106b915.json" source: "Contracts Finder" current_stage: "Tender" buyer: "THE UNIVERSITY OF MANCHESTER" published: "2023-04-24" --- # Integrated bioreactor platform for rapid scale-up and translation Buyer: THE UNIVERSITY OF MANCHESTER Current stage: Tender OCID: ocds-b5fd17-11896b9a-3ab9-452a-b23c-b2855106b915 [View canonical contract page](https://d3tenders.com/contract/?ocid=ocds-b5fd17-11896b9a-3ab9-452a-b23c-b2855106b915) [Download OCDS JSON](https://d3tenders.com/contract/ocds-b5fd17-11896b9a-3ab9-452a-b23c-b2855106b915.json) ## Summary The University of Manchester is seeking bids for an open procurement process titled "Integrated bioreactor platform for rapid scale-up and translation" within the chemical industry machinery category. This tender involves the provision of bioreactor capacity for microbial fermentation process development across different scales. The deadline for submission is 25th May 2023, with a contract period spanning from 19th June 2023 to 14th February 2024. The opportunity is located in Manchester, United Kingdom. This public procurement opportunity is suitable for small and medium-sized enterprises (SMEs) looking to engage in the production of bio-based chemicals. Businesses involved in laboratory equipment, industrial process control, and precision instruments will find this tender relevant. The University of Manchester is the buying organisation, managing this procurement process through an open procedure. Interested businesses can access the procurement documents via the university's portal to submit their bids. ## Notice This tender is being run on behalf of Dr James Winterburn, Reader in Chemical Engineering. Dr Winterburn led a successful BBSRC ALERT21 equipment bid "Integrated bioreactor platform for rapid scale-up and translation", which will provide significant bioreactor capacity for microbial fermentation process development, scale up and translation for a range of bio-based chemicals. The exploitation of bio-based production routes requires a thorough understanding of production strain performance and an ability to rapidly and effectively scale processes from millilitres to tens of litres. The bioreactor platform is intended to provide understanding of how process conditions at different volumes and variability across process parameters (e.g., mixing speeds, dissolved O2, pH), affect host cell performance. The integrated bioreactor platform will bridge across three scales, outlined below, and allow for rapid process development and ultimately support research translation. Small-scale: Parallel bioreactor system (500 mL, 6 vessels) for rapid parallel process development, strain testing and parameter optimization for microbial fermentations in batch, fed-batch and continuous cultivation, with off gas analysis capability Mid-scale (3L bioreactor system, four vessels): For initial scale up and process development work (e.g., confirmation of feeding profiles, metabolic profiling) and preliminary process analysis (including; yield, productivity, final titre) with off gas analysis capability. Also serves as the seed train for inoculum preparation for scale up to 40L. Large-scale feasibility (40L SIP bioreactor): To enable in-house demonstration of process technical feasibility, production of sufficient quantities of material for application testing and benchmarking and provision of data for robust techno-economic analysis which can be used as the basis for commercialisation, also with off gas analysis capability. Additional information: Information, formalities and necessary requirements to be met will be set out in the procurement documents, all of which are available via the University's procurement portal In-Tend - https://in-tendhost.co.uk/manchesteruniversity Is a Recurrent Procurement Type? : No ## Key Details | Field | Value | | --- | --- | | Publication source | Contracts Finder | | Latest notice | https://www.contractsfinder.service.gov.uk/Notice/480eae1a-a90d-4bd1-9bc7-dc6885b9edf7 | | Notice type | Tender Notice | | Procurement type | Standard | | Procurement category | Goods | | Procurement method | Open | | Procurement method details | Open procedure (above threshold) | | Tender suitability | SME | | Awardee scale | Not specified | | All stages | Tender | ## Dates | Field | Value | | --- | --- | | Publication date | 24 Apr 2023 | | Submission deadline | 25 May 2023 | | Future notice date | Not specified | | Award date | Not specified | | Contract period | 19 Jun 2023 - 14 Feb 2024 | | Recurrence | Not specified | ## Values | Field | Value | | --- | --- | | Tender value | Not specified | | Lots value | Not specified | | Awards value | Not specified | | Contracts value | Not specified | ## Status | Field | Value | | --- | --- | | Tender status | Active | | Lots status | Not specified | | Awards status | Not specified | | Contracts status | Not specified | ## Buyer | Field | Value | | --- | --- | | Main buyer | THE UNIVERSITY OF MANCHESTER | | Locality | MANCHESTER | | Post town | Manchester | | Postcode | M13 9PL | | Country | England | | ITL 1 | TLD North West (England) | | ITL 2 | TLD3 Greater Manchester | | ITL 3 | TLD33 Manchester | | Local authority | Manchester | | Electoral ward | Hulme | | Westminster constituency | Manchester Rusholme | | Delivery location | TLD North West (England) | ## CPV Codes ### Divisions - 38 - Laboratory, optical and precision equipments (excl. glasses) - 42 - Industrial machinery ### Codes - 38000000 - Laboratory, optical and precision equipments (excl. glasses) - 38800000 - Industrial process control equipment and remote-control equipment - 42993000 - Chemical industry machinery ## Release History - 24 Apr 2023 at 08:51 - TenderAmendment - Tender Notice - https://www.contractsfinder.service.gov.uk/Notice/480eae1a-a90d-4bd1-9bc7-dc6885b9edf7 - 24 Apr 2023 at 08:15 - Tender - Tender Notice - https://www.contractsfinder.service.gov.uk/Notice/480eae1a-a90d-4bd1-9bc7-dc6885b9edf7 ## Documents - https://www.contractsfinder.service.gov.uk/Notice/480eae1a-a90d-4bd1-9bc7-dc6885b9edf7 24th April 2023 - Opportunity notice on Contracts Finder - https://in-tendhost.co.uk/manchesteruniversity/aspx/ Additional information on how to apply for this contract ## Notice URLs - https://in-tendhost.co.uk/manchesteruniversity ## Provenance This Markdown file is an alternate public rendering of the D3 Tenders contract record. The canonical page is https://d3tenders.com/contract/?ocid=ocds-b5fd17-11896b9a-3ab9-452a-b23c-b2855106b915. The underlying structured data is available as OCDS JSON at https://d3tenders.com/contract/ocds-b5fd17-11896b9a-3ab9-452a-b23c-b2855106b915.json.