--- title: "Tender for the Supply and Installation of FRET/Ca2+ Imaging and 4-Camera TIRF Microscopes" ocid: "ocds-b5fd17-eb284efb-0d58-43ab-bfa4-9010c7c0f1b8" canonical_url: "https://d3tenders.com/contract/?ocid=ocds-b5fd17-eb284efb-0d58-43ab-bfa4-9010c7c0f1b8" markdown_url: "https://d3tenders.com/contract/ocds-b5fd17-eb284efb-0d58-43ab-bfa4-9010c7c0f1b8.md" json_url: "https://d3tenders.com/contract/ocds-b5fd17-eb284efb-0d58-43ab-bfa4-9010c7c0f1b8.json" source: "Contracts Finder" current_stage: "Tender" buyer: "UNIVERSITY OF BIRMINGHAM" published: "2017-10-09" --- # Tender for the Supply and Installation of FRET/Ca2+ Imaging and 4-Camera TIRF Microscopes Buyer: UNIVERSITY OF BIRMINGHAM Current stage: Tender OCID: ocds-b5fd17-eb284efb-0d58-43ab-bfa4-9010c7c0f1b8 [View canonical contract page](https://d3tenders.com/contract/?ocid=ocds-b5fd17-eb284efb-0d58-43ab-bfa4-9010c7c0f1b8) [Download OCDS JSON](https://d3tenders.com/contract/ocds-b5fd17-eb284efb-0d58-43ab-bfa4-9010c7c0f1b8.json) ## Summary The University of Birmingham is seeking tenders for the supply and installation of FRET/Ca2+ imaging and 4-camera TIRF microscopes under the title "Tender for the Supply and Installation of FRET/Ca2+ Imaging and 4-Camera TIRF Microscopes." This procurement falls under the industry category of microscopes and is in the active tender stage. The tender period will close on 8th November 2017, with the contract anticipated to commence on 1st December 2017 and run until 30th March 2018. The procurement method employed is an open procedure, enabling a wide range of suppliers to participate. This tender presents significant opportunities for businesses specialising in high-precision scientific equipment, especially those manufacturing advanced microscopy technologies. Companies that provide innovative solutions in imaging systems, particularly those capable of rapid acquisition and data analysis, would be well-suited to compete. This is an excellent chance for relevant SMEs to engage with a prestigious academic institution, enhancing their market presence and expanding their client base in the research sector. ## Notice The FRET/Ca2+ imaging and 4-camera TIRF microscopes are to be purchased by the Institute of Metabolism and Systems Research (IMSR), UoB. Match funding will be provided through COMPARE (http://www.birmingham-nottingham.ac.uk/compare/index.aspx). The systems will be housed in the recently refurbished rooms of the Centre of Membrane Proteins and Receptors (COMPARE). Access will be granted to members of COMPARE, as well as the intravital microscopy (IVM) user group. The specification below specifications outline the requirements for: a. A FRET/Ca2+ imaging microscope, which must be capable of performing fast high-sensitivity ratiometric imaging and photometric measurements in cells expressing FRET reporters or loaded with Ca2+ indictors (e.g. Fura-2). The system should be equipped with a monochromator for maximal flexibility and speed in the selection of the excitation wavelength, a dual-camera beam splitter, a very high sensitivity camera (EMCCD or equivalent). In addition, it should be equipped with a photomultiplier-based ratiometric acquisition system allowing ultrafast kinetics measurements (up to 100 microsecond temporal resolution). The system should also be equipped with a caged incubator for temperature control and a laminar-flow superfusion system (or more if needed) with compatible imaging chamber allowing both ultrarapid exchange of solutions (< 2 ms) and long superfusion times (up to 1 hour). The perfusion systems/imaging chambers/stage insets should be ideally interchangeable and could be shared between the two microscopes, allowing maximal flexibility. The microscope should be controlled by a user-friendly software, allowing the real-time monitoring of ratiometric FRET and Ca2+ traces and the control/recording of the triggers to/from the perfusion system(s). b. A 4-channel 2D/3D TIRF microscope for the analysis of both fast and slow dynamic biological processes (from few milliseconds to 1 hour) in living cells by single-molecule microscopy/single-particle tracking, superresolution microscopy methods such as 2D/3D PALM/dSTORM and single-molecule FRET. The system should also allow the fast and simultaneous acquisition of FRET between CFP and YFP by ratiometric imaging and single-molecule acquisition in the red or far-red channel. The system should also ideally allow to perform FRAP and/or uncaging experiments. The system should be equipped with suitable solid-state lasers of adequate power, a TIRF illuminator providing homogenous illumination, a quadruple camera beam-splitter and four fast EMCCD cameras. The microscope should be controlled by a user-friendly software, allowing fast synchronised real-time acquisition from the four cameras (>= 56 frames/s in normal full-frame 512x512 mode and >= 560 frames/s from a 128x128 sub-array in crop mode). The system should also be equipped with a caged incubator for temperature control and a laminar-flow superfusion system (or more if needed) with compatible imaging chambe... Additional information: Please log in or register to find documents at www.in-tendhost.com/universityofbirmingham Is a Recurrent Procurement Type? : No ## Key Details | Field | Value | | --- | --- | | Publication source | Contracts Finder | | Latest notice | https://www.contractsfinder.service.gov.uk/Notice/d30ef6a3-af4c-439e-9921-53c8bfaef304 | | Notice type | Tender Notice | | Procurement type | Standard | | Procurement category | Goods | | Procurement method | Open | | Procurement method details | Open procedure (above threshold) | | Tender suitability | SME | | Awardee scale | Not specified | | All stages | Tender | ## Dates | Field | Value | | --- | --- | | Publication date | 9 Oct 2017 | | Submission deadline | 8 Nov 2017 | | Future notice date | Not specified | | Award date | Not specified | | Contract period | 1 Dec 2017 - 30 Mar 2018 | | Recurrence | Not specified | ## Values | Field | Value | | --- | --- | | Tender value | Not specified | | Lots value | Not specified | | Awards value | Not specified | | Contracts value | Not specified | ## Status | Field | Value | | --- | --- | | Tender status | Active | | Lots status | Not specified | | Awards status | Not specified | | Contracts status | Not specified | ## Buyer | Field | Value | | --- | --- | | Main buyer | UNIVERSITY OF BIRMINGHAM | | Locality | EDGBASTON | | Post town | Birmingham | | Postcode | B15 2TT | | Country | England | | ITL 1 | TLG West Midlands (England) | | ITL 2 | TLG3 West Midlands | | ITL 3 | TLG31 Birmingham | | Local authority | Birmingham | | Electoral ward | Edgbaston | | Westminster constituency | Birmingham Edgbaston | | Delivery location | Not specified | ## CPV Codes ### Divisions - 38 - Laboratory, optical and precision equipments (excl. glasses) ### Codes - 38510000 - Microscopes ## Release History - 9 Oct 2017 at 10:47 - Tender - Tender Notice - https://www.contractsfinder.service.gov.uk/Notice/d30ef6a3-af4c-439e-9921-53c8bfaef304 ## Documents - https://www.contractsfinder.service.gov.uk/Notice/d30ef6a3-af4c-439e-9921-53c8bfaef304 9th October 2017 - Opportunity notice on Contracts Finder - https://in-tendhost.co.uk/universityofbirmingham/aspx/ Additional information on how to apply for this contract ## Notice URLs - http://www.birmingham-nottingham.ac.uk/compare/index.aspx ## Provenance This Markdown file is an alternate public rendering of the D3 Tenders contract record. The canonical page is https://d3tenders.com/contract/?ocid=ocds-b5fd17-eb284efb-0d58-43ab-bfa4-9010c7c0f1b8. The underlying structured data is available as OCDS JSON at https://d3tenders.com/contract/ocds-b5fd17-eb284efb-0d58-43ab-bfa4-9010c7c0f1b8.json.