---
title: "Automated Droplet Generator and Droplet Reader Equipment for the use in the manufacture of gene therapy drugs/treatment for research and development, education/teaching and training"
ocid: "ocds-h6vhtk-030de1"
canonical_url: "https://d3tenders.com/contract/?ocid=ocds-h6vhtk-030de1"
markdown_url: "https://d3tenders.com/contract/ocds-h6vhtk-030de1.md"
json_url: "https://d3tenders.com/contract/ocds-h6vhtk-030de1.json"
source: "Find A Tender Service"
current_stage: "Award"
buyer: "UNIVERSITY OF SHEFFIELD"
published: "2022-02-23"
---

# Automated Droplet Generator and Droplet Reader Equipment for the use in the manufacture of gene therapy drugs/treatment for research and development, education/teaching and training

Buyer: UNIVERSITY OF SHEFFIELD  
Current stage: Award  
OCID: ocds-h6vhtk-030de1

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## Summary

The University of Sheffield is conducting a tender process for an Automated Droplet Generator and Droplet Reader Equipment to support the establishment of its new Gene Therapy Innovation Manufacturing Centre (GTIMC) in Sheffield, set to advance gene therapy treatments for critical illnesses. The procurement, classified under the biomedical equipment category, falls under the "goods" category and has reached the Award stage. The current contract reflects an active status with the signing date on 21 January 2022, following a limited procurement method due to the specific technical requirements and absence of competitive alternatives.

This procurement opportunity is ideal for companies specialising in biomedical equipment and related services, particularly those with experience in the research sector. Manufacturers and suppliers capable of providing the specified droplet digital PCR systems and supporting services such as installation, training, and maintenance will find this an excellent prospect for collaboration. By participating in this tender, businesses can not only contribute to groundbreaking advancements in gene therapy but also become integral partners in boosting the UK's capacity for clinical vector manufacturing.

## Notice

The University of Sheffield (UoS) is establishing a new 'Gene Therapy Innovation Manufacturing Centre' (GTIMC) to advance scientific discoveries into life-changing treatments for patients with life threatening diseases. The Sheffield GTIMC will be one of three cutting edge hubs in the UK dedicated to advancing the clinical development of new genetic treatments. This facility is due to open in the Summer of 2022 and further details can be found at the following link:- https://www.sheffield.ac.uk/news/new-gene-therapy-innovation-centre-advance-scientific-discoveries-life-changing-treatments. The UoS requires an Automated Droplet Generator and Droplet Reader in order to undertake this co-ordinated work in parallel to other UK site - NHS Blood and Transplant (Bristol) working on identical methods and processes. To ensure the consistency of the science and comparability of the process development and results, the same equipment needs to be purchased as the other hub at NHSBT. GTIMC and NHSBT Hubs will use the same manufacturing platform being tech transferred from Cell and Gene Therapy Catapult.

### Lot Information

Lot 1

In order to assist with the tech transfer from Catapult the following item is being purchased asap: 1 x QX200 AutoDG ddPCR System AutoDG Droplet Digital PCR System for EvaGreen or probe-based digital PCR applications, includes Automated Droplet Generator, QX200 Droplet Reader, laptop computer, and QuantaSoft Software, Plate Sealer, Modular thermal cycler platform, plus other ancillary items/optional extras/ consumables. Between 2022 and 2027 the following items may be purchased:- 1 x QX200 AutoDG ddPCR System AutoDG Droplet Digital PCR System for EvaGreen or probe-based digital PCR applications, includes Automated Droplet Generator, QX200 Droplet Reader, laptop computer, and QuantaSoft Software, Plate Sealer, Modular thermal cycler platform, plus other ancillary items/optional extras/ consumables. The above equipment will be used to furnish one research and development lab and one clean room. Installation, commissioning, consumables, training and annual support/maintenance/calibration may be incorporated for between 3 and 5 years as part of the purchase.

### Procurement Information

The University of Sheffield signed an agreement with Cell and Gene Therapy Catapult (CGT Catapult) to tech transfer the Catapult AAV (Adeno-Associated Virus) manufacturing platform to Gene Therapy Innovation and Manufacturing Centre' (GTIMC). This task is one of the milestones under the funding award supporting the establishment of the GTIMC in Sheffield. The milestone must be completed within 12 months of the start of the GTIMC Project, i.e. by end July 2022. Any delay in the tech transfer will also impact on the milestone related to MHRA accreditation of GTIMC due by end Q4 2022. Using exactly the same equipment as the set up at Cell and Gene Therapy Catapult facilities will minimise delays and reduce time/avoid the need for optimisation of manufacturing protocols at GTIMC and allow us timely and within budget achievement of tech transfer milestones, optimisation using non generic equipment may introduce inconsistent results and invalidate the process which as a result would delay process, characterisation and final production processes. The GTIMC and University of Sheffield will jointly acquire a technology license from CGT Catapult to be able to use their AAV manufacturing platform. This platform was established and optimised based on the processes developed using the proposed list of equipment. The list of equipment (as set out herein) and the estimated timescales we plan to purchase was included in our proposal to the MRC/LifeArc to secure funding for the establishment of GTIMC in Sheffield. The subsequent Grant Offer includes the specific brands/models of equipment set out herein. A single source is therefore proposed to formalise the solution provided by Bio-Rad Laboratories Ltd for the following reasons: - This equipment has been identified and is currently used by CGT Catapult and therefore to not use the same equipment would invalidate the Tech Transfer processes and agreements Furthermore, this specific equipment and supplier was identified by CGT Catapult as the optimum type to produce the results and treatments for the better advancement of the process, deviation from this would require significant lengthy additional optimisation which would significantly delay the process and miss funding milestones and therefore minimise delays and reduce time/avoid the need for optimisation of manufacturing protocols at GTIMC and allow us timely and within budget achievement of tech transfer milestones, optimisation using different equipment may introduce inconsistent results and invalidate the process which as a result would delay process, characterisation and final production processes. Finally, the equipment set out herein will purely for the purpose of research, experiment, study or development within the University and no commercial licence will be held during the lifespan of this equipment. The prime functions of the GTIMC hub is to accelerate translational of gene therapy programs and clinical trials for rare monogenic diseases. To increase the U.K. capacity for GMP clinical vector manufacturing using the catapult process to allow for expansion of U.K. skills and training within the GTIMC space and increase partnerships with other academia which will create a fertile ecosystem for innovation and research excellence in this field across academia.

## Key Details

| Field | Value |
| --- | --- |
| Publication source | Find A Tender Service |
| Latest notice | https://www.find-tender.service.gov.uk/Notice/005061-2022 |
| Notice type | Award Notice |
| Procurement type | Standard |
| Procurement category | Goods |
| Procurement method | Limited |
| Procurement method details | Award procedure without prior publication of a call for competition |
| Tender suitability | Not specified |
| Awardee scale | Large |
| All stages | Award |

## Dates

| Field | Value |
| --- | --- |
| Publication date | 23 Feb 2022 |
| Submission deadline | Not specified |
| Future notice date | Not specified |
| Award date | 21 Jan 2022 |
| Contract period | Not specified |
| Recurrence | Not specified |

## Values

| Field | Value |
| --- | --- |
| Tender value | Not specified |
| Lots value | Not specified |
| Awards value | Not specified |
| Contracts value | £250,000 |

## Status

| Field | Value |
| --- | --- |
| Tender status | Complete |
| Lots status | Cancelled |
| Awards status | Active |
| Contracts status | Active |

## Buyer

| Field | Value |
| --- | --- |
| Main buyer | UNIVERSITY OF SHEFFIELD |
| Locality | SHEFFIELD |
| Post town | Sheffield |
| Postcode | S10 2TN |
| Country | England |
| ITL 1 | TLE Yorkshire and The Humber |
| ITL 2 | TLE3 South Yorkshire |
| ITL 3 | TLE32 Sheffield |
| Local authority | Sheffield |
| Electoral ward | Broomhill and Sharrow Vale |
| Westminster constituency | Sheffield Central |
| Delivery location | TLE32 Sheffield |

## Supplier

| Field | Value |
| --- | --- |
| Number of suppliers | 1 |
| Supplier names | BIO-RAD LABORATORIES |

## CPV Codes

### Divisions

- 38 - Laboratory, optical and precision equipments (excl. glasses)
- 51 - Installation services (except software)

### Codes

- 38434540 - Biomedical equipment
- 51430000 - Installation services of laboratory equipment

## Release History

- 23 Feb 2022 at 12:55 - Award - Award Notice - https://www.find-tender.service.gov.uk/Notice/005061-2022
- 21 Jan 2022 at 14:15 - Award - Award Notice - https://www.find-tender.service.gov.uk/Notice/001864-2022

## Notice URLs

- https://www.sheffield.ac.uk
- https://www.sheffield.ac.uk/news/new-gene-therapy-innovation-centre-advance-scientific-discoveries-life-changing-treatments

## Provenance

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