--- title: "CORRIGENDUM - The Procurement of Active Pharmaceutical Ingredient Physostigmine Free Base" ocid: "ocds-h6vhtk-033758" canonical_url: "https://d3tenders.com/contract/?ocid=ocds-h6vhtk-033758" markdown_url: "https://d3tenders.com/contract/ocds-h6vhtk-033758.md" json_url: "https://d3tenders.com/contract/ocds-h6vhtk-033758.json" source: "Find A Tender Service" current_stage: "Tender" buyer: "MINISTRY OF DEFENCE" published: "2022-10-26" --- # CORRIGENDUM - The Procurement of Active Pharmaceutical Ingredient Physostigmine Free Base Buyer: MINISTRY OF DEFENCE Current stage: Tender OCID: ocds-h6vhtk-033758 [View canonical contract page](https://d3tenders.com/contract/?ocid=ocds-h6vhtk-033758) [Download OCDS JSON](https://d3tenders.com/contract/ocds-h6vhtk-033758.json) ## Summary The Ministry of Defence, through the Defence Science and Technology Laboratory (Dstl), has issued a Prior Information Notice (PIN) titled "The Procurement of Active Pharmaceutical Ingredient Physostigmine Free Base." This procurement aims to explore the potential supply of Physostigmine Free Base over the next 5-7 years. The procurement falls under the main procurement category of goods and specifically focuses on other nervous system medicinal products. The process is currently in the planning stage, with a closing date for responses set on June 30, 2022. The opportunity is open to businesses that can engage in the development, process validation, manufacture, and supply of the API, with an indicative quantity of approximately 15kg to 20kg per annum. This tender presents an opportunity for businesses in the pharmaceutical sector to engage with Dstl and potentially supply Physostigmine Free Base to meet the Ministry of Defence's requirements. This engagement can lead to long-term supply contracts with the UK MOD. Companies with expertise in the development and supply of pharmaceutical products, particularly nervous system medicinal products, would be well-suited to compete in this procurement process. By providing feedback and information through the PIN questionnaire, businesses can influence the development of future Business Cases and Procurement Strategies, highlighting areas of opportunity and innovation. ## Notice The purpose of this Prior Information Notice (PIN) is to: * Share information on Dstl's current thinking regarding a requirement to supply a quantity of Physostigmine Free Base over the next 5-7 years, with the potential for a long term supply; * Obtain views & feedback on this from the market, including responses to the questions detailed in this document; * Provide the ability for the market to highlight areas of opportunity/innovation that Dstl are not currently aware of; * Use the feedback & information to inform & support the development of the future Business Case(s) & Procurement Strategy. This PIN questionnaire is not a request for a full proposal or bid nor should it be taken to be a call for competition, it is purely to obtain information from early engagement with the market. In supporting a potential wider MOD requirement, Dstl is currently exploring the availability & capacity within the market to supply a quantity of the Active Pharmaceutical Ingredient (API), Physostigmine Free Base (also known as eserine; chemical name 1,2,3,3ab,8,8ab-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b] indol-5-yl-methylcarbamate; chemical formula C15H21N3O2; molecular weight 275,36 g/mol). Under consideration is the development, process validation, manufacture & supply of this API with an outline indicative quantity of approx.15kg to 20kg per annum. The PIN questionnaire is seeking to identify where possible that the ultimate requirement is market facing/realistic/deliverable & the potential cost of the approach. Any information shared in response to the questionnaire, will be provided on the basis that it gives Dstl/UK MOD with free & unrestricted use of it in consideration of our requirement. It will not be shared outside of Dstl/UK MOD. Dstl is also interested in responses that propose different approaches or areas of efficiency that subject matter experts consider could be deemed in scope. Dstl gives no guarantee whatsoever that such proposals will be taken forward. ### Lot Information Lot 1 Prior Information Notice (PIN) Questionnaire - Procurement of Active Pharmaceutical Ingredient - Physostigmine Free Base Purpose: The purpose of this Prior Information Notice (PIN) questionnaire is to: * Share information on Dstl's current thinking regarding a requirement to supply a quantity of Physostigmine Free Base over the next 5-7 years, with the potential for a long term supply; * Obtain views and feedback on this from the market, including responses to the questions detailed in this document; * Provide the ability for the market to highlight areas of opportunity/innovation that Dstl are not currently aware of; * Use the feedback and information to inform and support the development of the future Business Case(s) and Procurement Strategy. This PIN questionnaire is not a request for a full proposal or bid nor should it be taken to be a call for competition, it is purely to obtain information from early engagement with the market. Background: In supporting a potential wider MOD requirement, Dstl is currently exploring the availability and capacity within the market to supply a quantity of the Active Pharmaceutical Ingredient (API), Physostigmine Free Base (also known as eserine; chemical name 1,2,3,3ab,8,8ab-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b] indol-5-yl-methylcarbamate; chemical formula C15H21N3O2; molecular weight 275,36 g/mol). Under consideration is the development, process validation, manufacture and supply of this API with an outline indicative quantity of approx. 15kg to 20kg per annum The Purpose of this PIN questionnaire is to assist in preparing a Business Case and Procurement Strategy for this future requirement. The PIN questionnaire is seeking feedback and advice from the market to help understand and to identify where possible that the ultimate requirement is market facing/realistic/deliverable and the potential cost of the approach; Please note that this is not a request for proposals or tenders at this stage. Any information shared with us in responses to the questionnaire, will be provided on the basis that it gives Dstl/UK MOD with the right to free and unrestricted use of it in consideration of our requirement. It will not, however, be shared outside of Dstl/UK MOD. Miscellaneous: Dstl is also interested in receiving responses that propose different approaches or areas of efficiency that subject matter experts in this field consider could be deemed to be in scope. Dstl gives no guarantee whatsoever that such proposals will be taken forward. ## Key Details | Field | Value | | --- | --- | | Publication source | Find A Tender Service | | Latest notice | https://www.find-tender.service.gov.uk/Notice/030232-2022 | | Notice type | Planning Notice | | Procurement type | Standard | | Procurement category | Goods | | Procurement method | Not Specified | | Procurement method details | Not specified | | Tender suitability | Not specified | | Awardee scale | Not specified | | All stages | Planning, Tender | ## Dates | Field | Value | | --- | --- | | Publication date | 26 Oct 2022 | | Submission deadline | Not specified | | Future notice date | 29 Apr 2023 | | Award date | Not specified | | Contract period | Not specified | | Recurrence | Not specified | ## Values | Field | Value | | --- | --- | | Tender value | Not specified | | Lots value | Not specified | | Awards value | Not specified | | Contracts value | Not specified | ## Status | Field | Value | | --- | --- | | Tender status | Planned | | Lots status | Planned | | Awards status | Not specified | | Contracts status | Not specified | ## Buyer | Field | Value | | --- | --- | | Main buyer | MINISTRY OF DEFENCE | | Locality | SALISBURY | | Post town | Salisbury | | Postcode | SP4 0JQ | | Country | England | | ITL 1 | TLK South West (England) | | ITL 2 | TLK7 Gloucestershire and Wiltshire | | ITL 3 | TLK72 Wiltshire | | Local authority | Wiltshire | | Electoral ward | Winterslow & Upper Bourne Valley | | Westminster constituency | Salisbury | | Delivery location | Not specified | ## CPV Codes ### Divisions - 33 - Medical equipments, pharmaceuticals and personal care products ### Codes - 33661700 - Other nervous system medicinal products ## Release History - 26 Oct 2022 at 14:44 - TenderUpdate - Tender Notice - https://www.find-tender.service.gov.uk/Notice/030232-2022 - 16 May 2022 at 11:23 - TenderUpdate - Tender Notice - https://www.find-tender.service.gov.uk/Notice/012624-2022 - 13 May 2022 at 11:29 - Planning - Planning Notice - https://www.find-tender.service.gov.uk/Notice/012474-2022 ## Notice URLs - https://contracts.mod.uk/go/940803330180BD2BBCCE - https://contracts.mod.uk/go/940803330180BD2BBCCEClosingdateforresponsestothisPINis30June202223:59GMT - https://www.gov.uk/government/organisations/defence-science-and-technology-laboratory ## Provenance This Markdown file is an alternate public rendering of the D3 Tenders contract record. The canonical page is https://d3tenders.com/contract/?ocid=ocds-h6vhtk-033758. The underlying structured data is available as OCDS JSON at https://d3tenders.com/contract/ocds-h6vhtk-033758.json.