--- title: "UKHSA In silico modelling of the Nucleocapsid protein of SARS-CoV-2" ocid: "ocds-h6vhtk-036b0a" canonical_url: "https://d3tenders.com/contract/?ocid=ocds-h6vhtk-036b0a" markdown_url: "https://d3tenders.com/contract/ocds-h6vhtk-036b0a.md" json_url: "https://d3tenders.com/contract/ocds-h6vhtk-036b0a.json" source: "Find A Tender Service" current_stage: "Tender" buyer: "SECRETARY OF STATE FOR HEALTH AND SOCIAL CARE ACTING AS PART OF THE CROWN THROUGH UK HEALTH SECURITY AGENCY" published: "2022-09-27" --- # UKHSA In silico modelling of the Nucleocapsid protein of SARS-CoV-2 Buyer: SECRETARY OF STATE FOR HEALTH AND SOCIAL CARE ACTING AS PART OF THE CROWN THROUGH UK HEALTH SECURITY AGENCY Current stage: Tender OCID: ocds-h6vhtk-036b0a [View canonical contract page](https://d3tenders.com/contract/?ocid=ocds-h6vhtk-036b0a) [Download OCDS JSON](https://d3tenders.com/contract/ocds-h6vhtk-036b0a.json) ## Summary The UK Health Security Agency (UKHSA) is planning a procurement process for in silico modelling of the Nucleocapsid protein of SARS-CoV-2. The buying organization is the Secretary of State for Health and Social Care acting as part of the Crown through UKHSA. This falls under the services category in the research and development services and related consultancy services industry. The procurement involves the development of an in-silico protein model to analyse mutations of the Nucleocapsid protein and their impact on lateral flow device sensitivity. The market engagement aims to identify potential suppliers, with an Expression of Interest closing on the 10th of October 2022. This tender presents an opportunity for businesses in the research and development services and consultancy sector. Potential suppliers with expertise in in silico modelling and bioinformatics are well-suited to compete. The procurement stage is at the planning phase with a future notice date set for November 10th, 2022. The tender value is £400,000 GBP, and the anticipated route to market will be a regulation 14 exemption under the Public Contracts Regulations 2015. The tender includes one lot focusing on the in silico analysis of SARS-CoV-2 mutations. Interested businesses can find more information on the UKHSA website and submit their Expression of Interest for the market engagement process. ## Notice Market Engagement for in silico analysis of the impact of mutations of the Nucleocapsid protein of SARS-CoV-2 on lateral flow device sensitivity. ### Lot Information Lot 1 Market Engagement - In silico analysis of the impact of mutations of the Nucleocapsid protein of SARS-CoV-2 on lateral flow device sensitivity. Atamis project reference: C103586 The UK Health Security Agency (UKHSA) wishes to inform the market of a potential future procurement to source a suitably qualified supplier (or an optimal combination of suppliers) to develop an in-silico protein model that can analyse the impact of mutations of the Nucleocapsid protein structure of SARS-CoV-2 and its subsequent impact on lateral flow device sensitivity. UKHSA notes that mutations of the Nucleocapsid protein of SARS-CoV-2 that are present in Variants of Concern (VoCs) can impact on the sensitivity of lateral flow devices. Hence, we are looking to procure a supplier to build an in-silico protein model of the Nucleocapsid protein that will allow UKHSA to quickly assess the impact of a mutation on lateral flow device performance. UKHSA evaluates the sensitivity of LFDs against SARS-CoV-2 in a 'wet' laboratory environment. This provides UKHSA with the data which is required to make decisions on the performance of lateral flow devices and this work will continue. However, it can take several weeks to perform the evaluation, depending on the availability of clinical samples. UKHSA is looking for a supplier to model the Nucleocapsid protein. The supplier will then use information on the binding sites for the lateral flow devices, to make a prediction of impact of a new variant on a lateral flow device's sensitivity. UKHSA hopes to receive the prediction within a few days of a new variant being sequenced. UKHSA wishes to explore the market, identify interest and potential solutions from suitably qualified suppliers who can provide in silico modelling solutions to refine our requirements and help shape any future procurement. Please note this Prior Information Notice (PIN) for market engagement is not meant for reducing the timeframe of the tender process. It is to enable UKHSA to assess the market for potential suppliers who may be interested in the upcoming future opportunity. The presently anticipated route to the market will be a regulation 14 exemption under the Public Contracts Regulations 2015 but will still be subject to a fair and open competition. If you are interested in participating in this market engagement, please confirm your Expression of Interest (EOI)via return response on Atamis ref C103586 regarding involvement in the market engagement and tender process. The expression of interest closes at 18:00 hrs on the 10th of October 2022. Please note that at any point after the closure of EOI and if required, we may invite potential suppliers who have expressed interest to this PIN for a further discussion to better understand their responses, this may include activities such as supplier days. ## Key Details | Field | Value | | --- | --- | | Publication source | Find A Tender Service | | Latest notice | https://www.find-tender.service.gov.uk/Notice/026982-2022 | | Notice type | Planning Notice | | Procurement type | Standard | | Procurement category | Services | | Procurement method | Not Specified | | Procurement method details | Not specified | | Tender suitability | Not specified | | Awardee scale | Not specified | | All stages | Planning, Tender | ## Dates | Field | Value | | --- | --- | | Publication date | 27 Sep 2022 | | Submission deadline | Not specified | | Future notice date | 10 Nov 2022 | | Award date | Not specified | | Contract period | Not specified | | Recurrence | Not specified | ## Values | Field | Value | | --- | --- | | Tender value | £400,000 | | Lots value | Not specified | | Awards value | Not specified | | Contracts value | Not specified | ## Status | Field | Value | | --- | --- | | Tender status | Planned | | Lots status | Planned | | Awards status | Not specified | | Contracts status | Not specified | ## Buyer | Field | Value | | --- | --- | | Main buyer | SECRETARY OF STATE FOR HEALTH AND SOCIAL CARE ACTING AS PART OF THE CROWN THROUGH UK HEALTH SECURITY AGENCY | | Locality | LONDON | | Post town | South West London | | Postcode | SW1P 3JR | | Country | England | | ITL 1 | TLI London | | ITL 2 | TLI3 Inner London - West | | ITL 3 | TLI35 Westminster and City of London | | Local authority | Westminster | | Electoral ward | St James's | | Westminster constituency | Cities of London and Westminster | | Delivery location | Not specified | ## CPV Codes ### Divisions - 73 - Research and development services and related consultancy services ### Codes - 73000000 - Research and development services and related consultancy services ## Release History - 27 Sep 2022 at 07:58 - TenderUpdate - Tender Notice - https://www.find-tender.service.gov.uk/Notice/026982-2022 - 23 Sep 2022 at 13:56 - Planning - Planning Notice - https://www.find-tender.service.gov.uk/Notice/026718-2022 ## Notice URLs - https://health-family.force.com/s/Welcome - https://www.gov.uk/government/organisations/uk-health-security-agency ## Provenance This Markdown file is an alternate public rendering of the D3 Tenders contract record. The canonical page is https://d3tenders.com/contract/?ocid=ocds-h6vhtk-036b0a. The underlying structured data is available as OCDS JSON at https://d3tenders.com/contract/ocds-h6vhtk-036b0a.json.