--- title: "Integrated bioreactor platform for rapid scale-up and translation" ocid: "ocds-h6vhtk-03c372" canonical_url: "https://d3tenders.com/contract/?ocid=ocds-h6vhtk-03c372" markdown_url: "https://d3tenders.com/contract/ocds-h6vhtk-03c372.md" json_url: "https://d3tenders.com/contract/ocds-h6vhtk-03c372.json" source: "Find A Tender Service" current_stage: "Tender" buyer: "UNIVERSITY OF MANCHESTER" published: "2023-04-24" --- # Integrated bioreactor platform for rapid scale-up and translation Buyer: UNIVERSITY OF MANCHESTER Current stage: Tender OCID: ocds-h6vhtk-03c372 [View canonical contract page](https://d3tenders.com/contract/?ocid=ocds-h6vhtk-03c372) [Download OCDS JSON](https://d3tenders.com/contract/ocds-h6vhtk-03c372.json) ## Summary The University of Manchester has initiated a tender process for the procurement of an "Integrated bioreactor platform for rapid scale-up and translation" in the goods category within the chemical industry machinery classification. The tender, with the ID 2023-2033-BRS-JW-PC, is being managed by Dr James Winterburn, Reader in Chemical Engineering. The contract period is set to run from June 8, 2023, to February 14, 2024. The tender submission deadline is May 25, 2023. The procurement method is an open procedure, and electronic submissions are required. The delivery location is at The University of Manchester. This tender presents an opportunity for businesses operating in the chemical industry machinery sector to provide an integrated bioreactor platform for microbial fermentation process development. Companies with expertise in manufacturing laboratory, optical, and precision equipment would be well-suited to compete. The University of Manchester, as the buying organization, is seeking to enhance its research capabilities in bio-based chemicals through this tender. Businesses interested in participating should ensure compliance with the bid validity period of 90 days and the submission requirements specified in the tender documentation. ## Notice This tender is being run on behalf of Dr James Winterburn, Reader in Chemical Engineering. Dr Winterburn led a successful BBSRC ALERT21 equipment bid "Integrated bioreactor platform for rapid scale-up and translation", which will provide significant bioreactor capacity for microbial fermentation process development, scale up and translation for a range of bio-based chemicals. The exploitation of bio-based production routes requires a thorough understanding of production strain performance and an ability to rapidly and effectively scale processes from millilitres to tens of litres. The bioreactor platform is intended to provide understanding of how process conditions at different volumes and variability across process parameters (e.g., mixing speeds, dissolved O2, pH), affect host cell performance. The integrated bioreactor platform will bridge across three scales, outlined below, and allow for rapid process development and ultimately support research translation. Small-scale: Parallel bioreactor system (500 mL, 6 vessels) for rapid parallel process development, strain testing and parameter optimization for microbial fermentations in batch, fed-batch and continuous cultivation, with off gas analysis capability Mid-scale (3L bioreactor system, four vessels): For initial scale up and process development work (e.g., confirmation of feeding profiles, metabolic profiling) and preliminary process analysis (including; yield, productivity, final titre) with off gas analysis capability. Also serves as the seed train for inoculum preparation for scale up to 40L. Large-scale feasibility (40L SIP bioreactor): To enable in-house demonstration of process technical feasibility, production of sufficient quantities of material for application testing and benchmarking and provision of data for robust techno-economic analysis which can be used as the basis for commercialisation, also with off gas analysis capability. ### Lot Information Lot 1 This tender is being run on behalf of Dr James Winterburn, Reader in Chemical Engineering. Dr Winterburn led a successful BBSRC ALERT21 equipment bid "Integrated bioreactor platform for rapid scale-up and translation", which will provide significant bioreactor capacity for microbial fermentation process development, scale up and translation for a range of bio-based chemicals. The exploitation of bio-based production routes requires a thorough understanding of production strain performance and an ability to rapidly and effectively scale processes from millilitres to tens of litres. The bioreactor platform is intended to provide understanding of how process conditions at different volumes and variability across process parameters (e.g., mixing speeds, dissolved O2, pH), affect host cell performance. The integrated bioreactor platform will bridge across three scales, outlined below, and allow for rapid process development and ultimately support research translation. Small-scale: Parallel bioreactor system (500 mL, 6 vessels) for rapid parallel process development, strain testing and parameter optimization for microbial fermentations in batch, fed-batch and continuous cultivation, with off gas analysis capability Mid-scale (3L bioreactor system, four vessels): For initial scale up and process development work (e.g., confirmation of feeding profiles, metabolic profiling) and preliminary process analysis (including; yield, productivity, final titre) with off gas analysis capability. Also serves as the seed train for inoculum preparation for scale up to 40L. Large-scale feasibility (40L SIP bioreactor): To enable in-house demonstration of process technical feasibility, production of sufficient quantities of material for application testing and benchmarking and provision of data for robust techno-economic analysis which can be used as the basis for commercialisation, also with off gas analysis capability. ## Key Details | Field | Value | | --- | --- | | Publication source | Find A Tender Service | | Latest notice | https://www.find-tender.service.gov.uk/Notice/011610-2023 | | Notice type | Tender Notice | | Procurement type | Standard | | Procurement category | Goods | | Procurement method | Open | | Procurement method details | Open procedure | | Tender suitability | Not specified | | Awardee scale | Not specified | | All stages | Tender | ## Dates | Field | Value | | --- | --- | | Publication date | 24 Apr 2023 | | Submission deadline | 25 May 2023 | | Future notice date | Not specified | | Award date | Not specified | | Contract period | 7 Jun 2023 - 14 Feb 2024 | | Recurrence | Not specified | ## Values | Field | Value | | --- | --- | | Tender value | Not specified | | Lots value | Not specified | | Awards value | Not specified | | Contracts value | Not specified | ## Status | Field | Value | | --- | --- | | Tender status | Active | | Lots status | Active | | Awards status | Not specified | | Contracts status | Not specified | ## Buyer | Field | Value | | --- | --- | | Main buyer | UNIVERSITY OF MANCHESTER | | Locality | MANCHESTER | | Post town | Manchester | | Postcode | M13 9PL | | Country | England | | ITL 1 | TLD North West (England) | | ITL 2 | TLD3 Greater Manchester | | ITL 3 | TLD33 Manchester | | Local authority | Manchester | | Electoral ward | Hulme | | Westminster constituency | Manchester Rusholme | | Delivery location | TLD3 Greater Manchester | ## CPV Codes ### Divisions - 38 - Laboratory, optical and precision equipments (excl. glasses) - 42 - Industrial machinery ### Codes - 38000000 - Laboratory, optical and precision equipments (excl. glasses) - 42993000 - Chemical industry machinery ## Release History - 24 Apr 2023 at 08:48 - Tender - Tender Notice - https://www.find-tender.service.gov.uk/Notice/011610-2023 ## Notice URLs - http://www.procurement.manchester.ac.uk/ - https://in-tendhost.co.uk/manchesteruniversity/aspx/Tenders/Current ## Provenance This Markdown file is an alternate public rendering of the D3 Tenders contract record. The canonical page is https://d3tenders.com/contract/?ocid=ocds-h6vhtk-03c372. The underlying structured data is available as OCDS JSON at https://d3tenders.com/contract/ocds-h6vhtk-03c372.json.