Award

OECD 488 transgenic rodent mutation assay (TGRA) using the Big Blue(r) rat

UNIVERSITY OF SHEFFIELD

This public procurement record has 1 release in its history.

Award

27 May 2022 at 13:03

Award Notice
Summary of the contracting process

The procurement process pertains to the University of Sheffield's tender titled "OECD 488 transgenic rodent mutation assay (TGRA) using the Big Blue® rat." This project is classified under the industry category of "Research laboratory services" and is located in Yorkshire and the Humber, United Kingdom. The procurement method is a limited negotiated procedure without prior publication, with a total contract value of £366,300. The tender period concluded on 13th May 2022, and the contract is set to commence on 14th May 2022 and run until 31st May 2023.

This tender presents significant opportunities for businesses focusing on research laboratory services, particularly those experienced in conducting GLP compliant assays and running studies involving transgenic models. Small and medium enterprises (SMEs) with a background in biochemistry, genetics, or laboratory services may find the requirements well-suited to their capabilities. Engaging with this contract could help businesses expand their portfolio and develop strong partnerships within the scientific research community.

Find more tenders on our Open Data Platform.
How relevant is this notice?

D3 Tenders Premium

Win More Public Sector Contracts

AI-powered tender discovery, pipeline management, and market intelligence — everything you need to grow your public sector business.

Start Free Trial Book a Demo
All Features Pricing

Notice Information

Notice Title

OECD 488 transgenic rodent mutation assay (TGRA) using the Big Blue(r) rat

Notice Description

The conduct of an OECD 488 transgenic rodent mutation assay (TGRA) using the Big Blue(r) rat using cII mutant selection for the University of Sheffield. Studies will be conducted to GLP, and are based on the following preliminary study design: 1. Breeding of target cohort of 46 Big Blue male rats, with delivery of a target of 44 rats to Charles River Laboratories (CRL) facility, Ashland Ohio, USA. 2. Transfer of HPLC analytical method for dose formulation analysis (DFA) and method transfer summary performed by CRL. 3. Method validation, homogeneity, solubility and stability work to enable GLP doseformulation analysis during Big Blue(r) TGRA main study, performed by CRL. 4. 7-day dose-range finding study (DRF), wild type Fischer F344 male and female rats, to determine limit dose of 1000 mg / kg body weight /day or MTD, performed by CRL. 5. Big Blue(r) TGRA rat main study, male only, using vehicle, 3 dose groups and concurrent positive control conducted at CRL. Each group will contain at least 6 male rats, conducted in accordance with OECD 488; daily test item administration by oral gavage for 28 days (positive control will be dosed days 1, 3, 10, 17 & 24 only); termination and schedule necropsy on day 31 with duodenum, liver and bone marrow removed from all animals, flash frozen and stored prior to shipment to Gentronix. 6. Pig-A in vivo mutation analysis will be integrated into the Big Blue(r) TGRA study, with all study animals screened for elevated Pig-A locus mutation in the pre-study acclimatisation phase, and then a blood sample taken from all animals on study on day 31 as a terminal bleed to minimise animal handling procedures and impact onto the Big Blue(r) TGRA study. 7. Dose formulation analysis during conduct of the main study, performed by CRL. 8. Analysis of liver and duodenum (bone marrow will not be analysed initially) from 5 animals per dose group in the in vitro phase of the Big Blue(r) TGRA study as per OECD 488 will be conducted at and performed by Gentronix. DNA will be extracted, packaged into lambda bacteriophage used to infect E. coli strain G1250 to determine phage packaging efficiency and cII mutation detection after plating on agar. Phage packaging titres of at least 125,000 per animal will be determined, to facilitate estimation of mutation frequency. 9. GLP reporting of results. F15: Voluntary ex ante transparency notice (2022/S 000-006619) and F03: Contract award notice (2022/S 000-014913) relate

Notice Details

Publication & Lifecycle

Open Contracting ID
ocds-b5fd17-e9b8c27c-841f-489e-b7d8-3406bcad23b8
Publication Source
Contracts Finder
Latest Notice
https://www.contractsfinder.service.gov.uk/Notice/8742fb2f-ea5a-4f40-bfc9-ef9633e27715
Current Stage
Award
All Stages
Award

Procurement Classification

Notice Type
Award Notice
Procurement Type
Standard
Procurement Category
Services
Procurement Method
Limited
Procurement Method Details
Negotiated procedure without prior publication (above threshold)
Tender Suitability
SME
Awardee Scale
SME

Common Procurement Vocabulary (CPV)

CPV Divisions

73 - Research and development services and related consultancy services

CPV Codes

73111000 - Research laboratory services

Notice Value(s)

Tender Value
£366,300 £100K-£500K
Lots Value
Not specified
Awards Value
£366,300 £100K-£500K
Contracts Value
Not specified

Notice Dates

Publication Date
27 May 20223 years ago
Submission Deadline
13 May 2022Expired
Future Notice Date
Not specified
Award Date
12 May 20223 years ago
Contract Period
13 May 2022 - 31 May 2023 1-2 years
Recurrence
Not specified

Notice Status

Tender Status
Complete
Lots Status
Not Specified
Awards Status
Active
Contracts Status
Not Specified

Buyer & Supplier

Contracting Authority (Buyer)

Main Buyer
UNIVERSITY OF SHEFFIELD
Contact Name
Jamie Shaw
Contact Email
jamie.shaw@sheffield.ac.uk
Contact Phone
01142221516

Buyer Location

Locality
SHEFFIELD
Postcode
S10 2TN
Post Town
Sheffield
Country
England
Major Region (ITL 1)
TLE Yorkshire and The Humber
Basic Region (ITL 2)
TLE3 South Yorkshire
Small Region (ITL 3)
TLE32 Sheffield
Delivery Location
TLE Yorkshire and The Humber
Local Authority
Sheffield
Electoral Ward
Broomhill and Sharrow Vale
Westminster Constituency
Sheffield Central

Supplier Information

Number of Suppliers
1
Supplier Name

GENTRONIX

Further Information

Notice Documents

Open Contracting Data Standard (OCDS)

View full OCDS Record for this contracting process

Download

The Open Contracting Data Standard (OCDS) is a framework designed to increase transparency and access to public procurement data in the public sector. It is widely used by governments and organisations worldwide to report on procurement processes and contracts. 

{
    "tag": [
        "compiled"
    ],
    "id": "ocds-b5fd17-e9b8c27c-841f-489e-b7d8-3406bcad23b8-2022-05-27T14:03:40+01:00",
    "date": "2022-05-27T14:03:40+01:00",
    "ocid": "ocds-b5fd17-e9b8c27c-841f-489e-b7d8-3406bcad23b8",
    "language": "en",
    "initiationType": "tender",
    "tender": {
        "id": "3351/SSA/JS",
        "title": "OECD 488 transgenic rodent mutation assay (TGRA) using the Big Blue(r) rat",
        "description": "The conduct of an OECD 488 transgenic rodent mutation assay (TGRA) using the Big Blue(r) rat using cII mutant selection for the University of Sheffield. Studies will be conducted to GLP, and are based on the following preliminary study design: 1. Breeding of target cohort of 46 Big Blue male rats, with delivery of a target of 44 rats to Charles River Laboratories (CRL) facility, Ashland Ohio, USA. 2. Transfer of HPLC analytical method for dose formulation analysis (DFA) and method transfer summary performed by CRL. 3. Method validation, homogeneity, solubility and stability work to enable GLP doseformulation analysis during Big Blue(r) TGRA main study, performed by CRL. 4. 7-day dose-range finding study (DRF), wild type Fischer F344 male and female rats, to determine limit dose of 1000 mg / kg body weight /day or MTD, performed by CRL. 5. Big Blue(r) TGRA rat main study, male only, using vehicle, 3 dose groups and concurrent positive control conducted at CRL. Each group will contain at least 6 male rats, conducted in accordance with OECD 488; daily test item administration by oral gavage for 28 days (positive control will be dosed days 1, 3, 10, 17 & 24 only); termination and schedule necropsy on day 31 with duodenum, liver and bone marrow removed from all animals, flash frozen and stored prior to shipment to Gentronix. 6. Pig-A in vivo mutation analysis will be integrated into the Big Blue(r) TGRA study, with all study animals screened for elevated Pig-A locus mutation in the pre-study acclimatisation phase, and then a blood sample taken from all animals on study on day 31 as a terminal bleed to minimise animal handling procedures and impact onto the Big Blue(r) TGRA study. 7. Dose formulation analysis during conduct of the main study, performed by CRL. 8. Analysis of liver and duodenum (bone marrow will not be analysed initially) from 5 animals per dose group in the in vitro phase of the Big Blue(r) TGRA study as per OECD 488 will be conducted at and performed by Gentronix. DNA will be extracted, packaged into lambda bacteriophage used to infect E. coli strain G1250 to determine phage packaging efficiency and cII mutation detection after plating on agar. Phage packaging titres of at least 125,000 per animal will be determined, to facilitate estimation of mutation frequency. 9. GLP reporting of results. F15: Voluntary ex ante transparency notice (2022/S 000-006619) and F03: Contract award notice (2022/S 000-014913) relate",
        "status": "complete",
        "classification": {
            "scheme": "CPV",
            "id": "73111000",
            "description": "Research laboratory services"
        },
        "items": [
            {
                "id": "1",
                "deliveryAddresses": [
                    {
                        "region": "Yorkshire and the Humber",
                        "countryName": "United Kingdom"
                    }
                ]
            }
        ],
        "value": {
            "amount": 366300,
            "currency": "GBP"
        },
        "procurementMethod": "limited",
        "procurementMethodDetails": "Negotiated procedure without prior publication (above threshold)",
        "tenderPeriod": {
            "endDate": "2022-05-13T17:00:00+01:00"
        },
        "contractPeriod": {
            "startDate": "2022-05-14T00:00:00+01:00",
            "endDate": "2023-05-31T23:59:59+01:00"
        },
        "suitability": {
            "sme": true,
            "vcse": false
        },
        "mainProcurementCategory": "services"
    },
    "parties": [
        {
            "id": "GB-SRS-sid4gov.cabinetoffice.gov.uk/JYFy743W",
            "name": "UNIVERSITY OF SHEFFIELD",
            "identifier": {
                "legalName": "UNIVERSITY OF SHEFFIELD",
                "scheme": "GB-SRS",
                "id": "sid4gov.cabinetoffice.gov.uk/JYFy743W"
            },
            "address": {
                "streetAddress": "Western Bank",
                "locality": "SHEFFIELD",
                "postalCode": "S102TN",
                "countryName": "England"
            },
            "contactPoint": {
                "name": "Jamie Shaw",
                "email": "jamie.shaw@sheffield.ac.uk",
                "telephone": "01142221516"
            },
            "roles": [
                "buyer"
            ]
        },
        {
            "id": "GB-COH-03810162",
            "name": "GENTRONIX LIMITED",
            "identifier": {
                "legalName": "GENTRONIX LIMITED",
                "scheme": "GB-COH",
                "id": "03810162"
            },
            "address": {
                "streetAddress": "Alderley Park Cheshire East M13 9NT GB"
            },
            "details": {
                "scale": "sme",
                "vcse": false
            },
            "roles": [
                "supplier"
            ]
        }
    ],
    "buyer": {
        "id": "GB-SRS-sid4gov.cabinetoffice.gov.uk/JYFy743W",
        "name": "UNIVERSITY OF SHEFFIELD"
    },
    "awards": [
        {
            "id": "ocds-b5fd17-e9b8c27c-841f-489e-b7d8-3406bcad23b8-1",
            "status": "active",
            "date": "2022-05-13T00:00:00+01:00",
            "datePublished": "2022-05-27T14:03:40+01:00",
            "value": {
                "amount": 366300,
                "currency": "GBP"
            },
            "suppliers": [
                {
                    "id": "GB-COH-03810162",
                    "name": "GENTRONIX LIMITED"
                }
            ],
            "contractPeriod": {
                "startDate": "2022-05-14T00:00:00+01:00",
                "endDate": "2023-05-31T23:59:59+01:00"
            },
            "documents": [
                {
                    "id": "1",
                    "documentType": "awardNotice",
                    "description": "Awarded contract notice on Contracts Finder",
                    "url": "https://www.contractsfinder.service.gov.uk/Notice/8742fb2f-ea5a-4f40-bfc9-ef9633e27715",
                    "datePublished": "2022-05-27T14:03:40+01:00",
                    "format": "text/html",
                    "language": "en"
                }
            ]
        }
    ]
}