Notice Information
Notice Title
UK Research and Innovation - Oligonucleotide Synthesis and Nucleic Acid Sequencing Services Framework
Notice Description
***This is an Award Notice, Not a Call for Competition**** This Framework has been established for the provision of UK Research and Innovation: Oligonucleotide Synthesis and Nucleic Acid Sequencing Services . This Framework is being Established for a term of 3 years + 1 year
Lot Information
DNA Sequencing Services
UKRI wish to put in place a Framework for the purchase of a range of user selectable DNA Sequencing services (Sanger/ ~800-1000 base pair read) from a range of samples and formats including tubes, microtiter plates, preparation & extractions services including from colonies and tissue, with the capability of sequencing from High GC and AT samples.
Custom Gene SynthesisUKRI wish to put in place a Framework for the purchase of a user selectable range of Custom Gene Synthesis. It is anticipated that this will be divided into 4 sub lots: * Sub lot 2.1 - Custom Gene fragment synthesis (sub 2000bp) * Sub lot 2.2 - Custom Gene fragment synthesis (sub 3000bp) * Sub lot 2.3 - Custom Gene synthesis (3001-5000bp) * Sub lot 2.4 - Custom Gene synthesis (5001+ bp) For the above sub-lots, a range of user selectable additional services should be available. These are to include, but not limited to the following: * Genes produced with additional synthetic Nucleotides (AGTC + XY) * Custom vector production * Codon optimized sequences - all species * Site-directed mutagenesis * Bacterial, yeast, Baculovirus and mammalian gene expression services * Complex sequence synthesis - GC rich, AT rich, complex repeats & hairpin structures and toxic sequences
Advanced DNA ServicesUKRI wish to put in place a Framework for the purchase of a user selectable (via supplier engagement) range of advanced DNA services. It is anticipated that this will be divided into 3 sub lots: * Sub-lot 3.1 - Gene Specific DNA Methylation * Sub-lot 3.2 - Global DNA Methylation * Sub-lot 3.3 - Allele quantification A range of additional advanced DNA services are required to include, but not limited to: * Perform Bisulfite modification. * Perform PCR reactions. * Perform Pyrosequencing analysis. * LC MS DNA-methylation analysis. * ELISA that enables the direct quantitation of genomic DNA methylation. * PCR based methods e.g.; Alu and LINE1. * Methylation sensitive restriction assays e.g.; luminometric methylation assay (LUMA). * SNP detection and quantification. * Assay development for SNP detection and quantification from pooled DNA with a defined 100bp target region in murine DNA. * Validation of the above assay. * Sample testing if required for the above assay.
Custom OligonucleotidesUKRI wish to put in place a framework for the purchase of a range of custom Oligonucleotide synthesis services including Custom DNA oligo's in tubes, plates and RNA/siRNA, to be user selectable via supplier engagement with a range of purification and modification options. It is anticipated that this will be split into 2 sub lots: * Sub lot 4.1 - synthesis of DNA oligonucleotides. * Sub lot 4.2 - synthesis of Custom RNA oligo's (both Single and double stranded RNA oligoes, siRNA) the supply of siRNA Libraries and the production of custom SiRNA Libraries UKRI wish to put in place a framework for the purchase of a range of custom Oligonucleotide synthesis services including Custom DNA oligo's in tubes, plates and RNA/siRNA, to be user selectable via supplier engagement with a range of purification and modification options. Synthesis of DNA oligonucleotides, synthesis of Custom RNA oligo's (both Single and double stranded RNA oligoes, siRNA) the supply of siRNA Libraries and the production of custom SiRNA Libraries but not limited to: The production of custom user defined oligonucleotides in the following ranges are required (Inc. plates) * 0.01UM bases standard * 0.05UM bases standard * 0.2UM bases standard * 1.0UM bases standard * 0.025 UM / 3OD * Microtiter plates
Sub Lot 1.1Sub lot 1.1 - First Generation Nucleic Acid sequencing services For the above sub lot, UKRI wish to put in place a framework for the purchase of a range of user selectable Nucleic Acid sequencing (Sanger/ ~800-1000 base pair read) services to be provided. This could include but is not limited to the following: * Provide Phred 20 quality for as many nucleotides per sample as possible (min 800 bp or above for 5' 3' reads). * Provide purification and sequencing of plasmids and PCR products in both 1.5 ml tubes and microtiter plates (must offer 96 well as a minimum). * Provide purification and sequencing of plasmids supplied as Escherichia coli clones in both 1.5 ml tubes and microtiter plates (must offer 96 well as a minimum). * Provide sequencing services using both primers synthesized by supplier and those with user provided primers. * Provide Primer walking services in both double and single stranded DNA.
Renewal: This contract is being let on a 3 year + 1 year basis
Sub Lot 1.2 - Second Generation Nucleic Acid Sequencing ServicesSub lot 1.2 - Second Generation Nucleic Acid sequencing services For the above sub lot, UKRI wish to put in place a framework for the purchase of a range of Second Generation sequencing services from a range of samples and formats including tubes, microtiter plates, preparation & extractions services including from colonies and tissue samples. A range of user selectable Nucleic Acid sequencing services are required that could include but not limited to: * Ligation or sequencing by synthesis * Pyrosequencing * Dye sequencing * Semiconductor based sequencing * Provide sample pick-up or sample mailing/courier service as required. * Provide purification and sequencing of samples supplied * Offer suitable solutions to templates failing to give readable results
Renewal: This Contract is being let on a 3 years + 1 year basis
Sub Lot 1.3 - Third Generation Nucleic Acid Sequencing ServicesSub lot 1.3 - Third Generation Nucleic Acid sequencing services For the above Sub Lot, UKRI wish to put in place a framework for the purchase of a range of Third generation sequencing services from a range of samples and formats including tubes, microtiter plates, preparation & extractions services including from colonies and tissue samples utilising novel or 'next generation technologies. A range of user selectable Nucleic Acid sequencing services are required that could include but not limited to: * PCR determination * combinatorial probe-anchor synthesis (cPAS) * fluorescently labelled antibody binding sequencing * Single-molecule real-time (SMRT) sequencing * zero-mode waveguide sequencing * sequencing of DNA via Nano pore transition
Renewal: This contract is being Let on a 3 years + 1 year basis
Sub Lot 2.1 - Custom Gene fragment synthesis (sub 2000bp)Sub lot 2.1 - Custom Gene fragment synthesis (sub 2000bp) UKRI wish to put in place a framework for the purchase of a user selectable (via supplier engagement) range of Custom Gene Synthesis (sub 2000bp). For the above sub lot, a range of user selectable additional services should be available (but are not mandatory). This could include but is not limited to the following: * Genes produced with additional synthetic Nucleotides (AGTC + XY) * Custom vector production * Codon optimized sequences - all species * Site-directed mutagenesis * Bacterial, yeast, Baculovirus and mammalian gene expression services * Complex sequence synthesis - GC rich, AT rich, complex repeats & hairpin structures and toxic sequences
Renewal: This Contract is being Let on a 3 Year + 1 year basis
Sub Lot 2.2 - Custom Gene synthesis (2001 - 3000bp)UKRI wish to put in place a framework for the purchase of a user selectable (via supplier engagement) range of Custom Gene Synthesis (2001 - 3000bp). For the above sub lot, a range of user selectable additional services should be available (but are not mandatory). This could include but is not limited to the following: * Genes produced with additional synthetic Nucleotides (AGTC + XY) * Custom vector production * Codon optimized sequences - all species * Site-directed mutagenesis * Bacterial, yeast, Baculovirus and mammalian gene expression services * Complex sequence synthesis - GC rich, AT rich, complex repeats & hairpin structures and toxic sequences
Renewal: This Contract is being Let on a 3 year + 1 year basis
Sub Lot 2.3 - Custom Gene synthesis (3001-5000bp)Sub Lot 2.3 - Custom Gene synthesis (3001-5000bp) UKRI wish to put in place a framework for the purchase of a user selectable (via supplier engagement) range of Custom Gene Synthesis (3001 - 5000bp). For the above sub lot, a range of user selectable additional services should be available (but are not mandatory). This could include but is not limited to the following: * Genes produced with additional synthetic Nucleotides (AGTC + XY) * Custom vector production * Codon optimized sequences - all species * Site-directed mutagenesis * Bacterial, yeast, Baculovirus and mammalian gene expression services * Complex sequence synthesis - GC rich, AT rich, complex repeats & hairpin structures and toxic sequences
Renewal: This Contract is being Let on a 3 year + 1 year basis
Sub Lot 2.4 - Custom Gene synthesis (5001+ bp)UKRI wish to put in place a framework for the purchase of a user selectable (via supplier engagement) range of Custom Gene Synthesis (5001 + bp). For the above sub lot, a range of user selectable additional services should be available (but are not mandatory). This could include but is not limited to the following: * Genes produced with additional synthetic Nucleotides (AGTC + XY) * Custom vector production * Codon optimized sequences - all species * Site-directed mutagenesis * Bacterial, yeast, Baculovirus and mammalian gene expression services * Complex sequence synthesis - GC rich, AT rich, complex repeats & hairpin structures and toxic sequences
Renewal: This Contract is being Let on a 3 year + 1 year basis
Sub Lot 3.1 - Gene Specific DNA MethylationSub Lot 3.1 - Gene Specific DNA Methylation UKRI wish to put in place a Framework for the purchase of a range of Gene Specific DNA Methylation services are required to include, but not limited to: o Perform Bisulfite modification. o Perform PCR reactions. o Perform Pyrosequencing analysis.
Renewal: This Contract is being let on a 3 year + 1 year basis
Sub Lot 3.2 - Global DNA MethylationSub Lot 3.2 - Global DNA Methylation UKRI wish to put in place a Framework for the purchase of a range of global DNA methylation services are required to include, but not limited to: o LC MS DNA-methylation analysis. o ELISA that enables the direct quantitation of genomic DNA methylation. o PCR based methods e.g.; Alu and LINE1. o Methylation sensitive restriction assays e.g.; luminometric methylation assay (LUMA).
Renewal: This Contract is being Let on a 3 year + 1 year basis
Sub Lot 3.3 - Allele QuantificationSub Lot 3.3 - Allele quantification UKRI wish to put in place a Framework for the purchase of a range of Allele quantification services are required to include, but not limited to: o SNP detection and quantification. o Assay development for SNP detection and quantification from pooled DNA with a defined 100bp target region in murine DNA. o Validation of the above assay. o Sample testing if required for the above assay.
Renewal: This Contract is being Let on a 3 year + 1 year basis
Sub Lot 4.1 - Synthesis of DNA OligonucleotidesSub Lot 4.1 - Synthesis of DNA oligonucleotides. UKRI wish to put in place a framework for the purchase of a range of custom Oligonucleotide synthesis services including Custom DNA oligo's in tubes, plates and RNA/siRNA, to be user selectable via supplier engagement with a range of purification and modification options. The production of custom user defined oligonucleotides in the following ranges are required (Inc. plates). * 0.01UM bases standard * 0.05UM bases standard * 0.2UM bases standard * 1.0UM bases standard * 0.025 UM / 3OD * Microtiter plates
Renewal: This Contract is being Let on a 3 year + 1 year basis
Sub Lot 4.2 - Synthesis of Custom RNA Oligo's (both Single and double stranded RNA oligoes, siRNA) the supply of siRNA Libraries and the production of custom SiRNA LibrariesSub Lot 4.2 - Synthesis of Custom RNA oligo's (both Single and double stranded RNA oligoes, siRNA) the supply of siRNA Libraries and the production of custom SiRNA Libraries UKRI wish to put in place a framework for the purchase of a range of custom Oligonucleotide synthesis services including Custom DNA oligo's in tubes, plates and RNA/siRNA, to be user selectable via supplier engagement with a range of purification and modification options. The production of custom user defined oligonucleotides in the following ranges are required (Inc. plates). * 0.01UM bases standard * 0.05UM bases standard * 0.2UM bases standard * 1.0UM bases standard * 0.025 UM / 3OD * Microtiter plates
Renewal: This Contract is being Let on a 3 year + 1 year basis
Notice Details
Publication & Lifecycle
- Open Contracting ID
- ocds-h6vhtk-03f0a6
- Publication Source
- Find A Tender Service
- Latest Notice
- https://www.find-tender.service.gov.uk/Notice/019387-2024
- Current Stage
- Award
- All Stages
- Planning, Tender, Award
Procurement Classification
- Notice Type
- Planning Notice
- Procurement Type
- Framework
- Procurement Category
- Services
- Procurement Method
- Open
- Procurement Method Details
- Open procedure
- Tender Suitability
- Not specified
- Awardee Scale
- Large, SME
Common Procurement Vocabulary (CPV)
- CPV Divisions
24 - Chemical products
73 - Research and development services and related consultancy services
-
- CPV Codes
24956000 - Peptones and protein substances
73000000 - Research and development services and related consultancy services
73110000 - Research services
Notice Value(s)
- Tender Value
- £8,000,000 £1M-£10M
- Lots Value
- Not specified
- Awards Value
- Not specified
- Contracts Value
- Not specified
Notice Dates
- Publication Date
- 25 Jun 20241 years ago
- Submission Deadline
- 23 Oct 2023Expired
- Future Notice Date
- 30 Aug 2023Expired
- Award Date
- 30 Apr 20241 years ago
- Contract Period
- Not specified - Not specified
- Recurrence
- Not specified
Notice Status
- Tender Status
- Complete
- Lots Status
- Cancelled, Planned
- Awards Status
- Active
- Contracts Status
- Active
Buyer & Supplier
Contracting Authority (Buyer)
- Main Buyer
- UK RESEARCH AND INNOVATION
- Contact Name
- Goods and Self Service
- Contact Email
- coreservices@uksbs.co.uk
- Contact Phone
- +44 1793867005
Buyer Location
- Locality
- SWINDON
- Postcode
- SN2 1UH
- Post Town
- Swindon
- Country
- England
-
- Major Region (ITL 1)
- TLK South West (England)
- Basic Region (ITL 2)
- TLK7 Gloucestershire and Wiltshire
- Small Region (ITL 3)
- TLK71 Swindon
- Delivery Location
- Not specified
-
- Local Authority
- Swindon
- Electoral Ward
- Rodbourne Cheney
- Westminster Constituency
- Swindon North
Further Information
Open Contracting Data Standard (OCDS)
View full OCDS Record for this contracting process
The Open Contracting Data Standard (OCDS) is a framework designed to increase transparency and access to public procurement data in the public sector. It is widely used by governments and organisations worldwide to report on procurement processes and contracts.
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},
{
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