Notice Information
Notice Title
Utilising in silico, in vitro and 'omics New Approach Methodologies (NAMs) for priority-setting and safety assessment of tropane alkaloids (TAs) and other plant toxins as potential food contaminants. A case study for progressing the acceptance of NAMs for
Notice Description
Tenders were invited to carry out a range of project delivery options, to deliver against stages 1, 2 and 3 as described below: Stage 1: This case study is to support the UK FSA's policy need to determine which TAs are the most potent (neuro)toxicants so as to prioritise specific substances and inform decisions on the UK's monitoring of these alkaloids in foods. An integral part of this aim is to confirm that neurotoxicity is the primary mode of action of these alkaloids. This aim will be achieved using a tiered-testing strategy of in silico, in vitro and 'omics NAMs. This will then be extended to other plant alkaloids such as glycoalkaloids and pyridazine alkaloids. Stage 2: To derive a HBGV for human exposure for the top priority, i.e. most potent substance within the class of TAs. This will utilise physiologically-based kinetic (PBK) modelling and quantitative in vitro to in vivo extrapolation (QIVIVE). This will then be extended to other plant alkaloids such as glycoalkaloids and pyridazine alkaloids. Stage 3: From a methodological perspective, a broader third objective of the case study is to evaluate and attempt to build confidence within the FSA in the application of a series of relevant NAMs that have been integrated in a manner to address policy needs. These NAMs are tiered and incorporate existing human in vivo data as well as new testing on human in vitro cell lines, to maximise the relevance and accuracy to human food safety. Please note contract start date is 22/09/2025
Procurement Information
University of Birmingham have IPR rights to the systems that will be used as part of the case study.
Notice Details
Publication & Lifecycle
- Open Contracting ID
- ocds-h6vhtk-0565d3
- Publication Source
- Find A Tender Service
- Latest Notice
- https://www.find-tender.service.gov.uk/Notice/068648-2025
- Current Stage
- Award
- All Stages
- Award
Procurement Classification
- Notice Type
- UK7 - Contract Details Notice
- Procurement Type
- Standard
- Procurement Category
- Services
- Procurement Method
- Direct
- Procurement Method Details
- Direct award
- Tender Suitability
- SME, VCSE
- Awardee Scale
- Large
Common Procurement Vocabulary (CPV)
- CPV Divisions
73 - Research and development services and related consultancy services
-
- CPV Codes
73000000 - Research and development services and related consultancy services
73110000 - Research services
73200000 - Research and development consultancy services
Notice Value(s)
- Tender Value
- Not specified
- Lots Value
- Not specified
- Awards Value
- £488,375 £100K-£500K
- Contracts Value
- £488,375 £100K-£500K
Notice Dates
- Publication Date
- 27 Oct 20253 months ago
- Submission Deadline
- Not specified
- Future Notice Date
- Not specified
- Award Date
- 24 Jul 20257 months ago
- Contract Period
- 24 Sep 2025 - 31 May 2028 2-3 years
- Recurrence
- Not specified
Notice Status
- Tender Status
- Complete
- Lots Status
- Complete
- Awards Status
- Active, Pending
- Contracts Status
- Active
Buyer & Supplier
Contracting Authority (Buyer)
- Main Buyer
- FOOD STANDARDS AGENCY
- Contact Name
- FSA Commercial
- Contact Email
- fsa.commercial@food.gov.uk
- Contact Phone
- Not specified
Buyer Location
- Locality
- YORK
- Postcode
- YO1 7PR
- Post Town
- York
- Country
- England
-
- Major Region (ITL 1)
- TLE Yorkshire and The Humber
- Basic Region (ITL 2)
- TLE2 North Yorkshire
- Small Region (ITL 3)
- TLE21 York
- Delivery Location
- Not specified
-
- Local Authority
- York
- Electoral Ward
- Guildhall
- Westminster Constituency
- York Central
Further Information
Notice Documents
-
https://www.find-tender.service.gov.uk/Notice/068648-2025
27th October 2025 - Contract details notice on Find a Tender -
https://www.find-tender.service.gov.uk/Notice/054952-2025
9th September 2025 - Contract award notice on Find a Tender -
https://www.find-tender.service.gov.uk/Notice/042934-2025
24th July 2025 - Transparency notice on Find a Tender
Open Contracting Data Standard (OCDS)
View full OCDS Record for this contracting process
The Open Contracting Data Standard (OCDS) is a framework designed to increase transparency and access to public procurement data in the public sector. It is widely used by governments and organisations worldwide to report on procurement processes and contracts.
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