NCA30964 DRI Multi-photon 2021

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    "description": "The following features are unique to the 3D Neuralight system - as compared to other commercially available 2-photon microscopes - and are essential to our research programme: 1. Given that we used the mouse primary visual cortex (V1) as a model to investigate changes in neuronal connectivity during Alzheimer's disease, it is crucial to visualize the activity of neurons across this whole brain region - which in the mouse spans over 1.6 mm in diameter, approximately. The 3D Neuralight two-photon microscope has a scanning field-of-view (FOV) of 1.4mm x 1.4mm which allow to visualize this brain region almost entirely. This is largest FOV of any commercial system and achieved through having a unique field number of 28mm. 2. Because the primary visual cortex is around 0.6 mm deep, it is critical to rapidly monitor the activity of neurons located at different cortical depth (layers). To this purpose, the Neuralight 3D includes a unique electrically tunable lens (ETL) capable of fast imaging in multiple depths (up to 0.45mm with variable step sizes) without physically moving the microscope objective. As such, this technology is much faster and accurate than conventional piezos devices used in other commercial system that mechanically move the objective up and down. Importantly, the ETL allow for the decoupling of the stimulation and imaging path, so that the photostimulated neurons and the imaged neurons can be at different cortical depth. No other commercial system provides a proven ETL in conjunction with a Spatial -Light Modulator (SLM). 3. As part of our research programme, we will also investigate the dynamics of neuronal activity in freely moving animals using miniature microscopes developed by Inscopix. Although the miniscopes allow studies in moving animals, it lacks the high-resolution of two-photon imaging in head-fixed animals. Through a collaboration, Bruker and Inscopix developed an adapter called the MIRA (Multimodal Imaging and Registration Analysis) to image the same population of neurons with the Inscopix miniscope and the Bruker two-photon microscope. Bruker is the only multiphoton company with proven integration with the Inscopix Miniscope system. All in all, the specific features of the Bruker 3D Neuralight two-photon microscope are not only essential to meet the objectives of our research programme, but it is also the only multi-photon system available carrying all these features. Although other multiphoton suppliers have started to implement the SLM technology for stimulation and imaging- they all lack the large field-of-view, rapid volumetric imaging in the z-plane using ETL and the capability to integrate it with the miniscope technology- all crucial aspects of our research. (SC Ref:663782)",
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        "description": "This unique multi-photon microscope has the ability to simultaneously activate individual neurons while imaging a whole brain region (e.g. primary visual cortex). This technology - currently unavailable in Scotland and adopted by only a few laboratories in the world- would allow us to investigate the changes in neuronal connectivity that may underlie memory formation - as well as memory dysfunction in Alzheimer's disease animal models. As such, this technology will not only allow us to generate new knowledge that hold the promise to open therapeutical avenues for Alzheimer's disease that will benefit societies around the world, but it will also provide better training to early career researchers by providing access to innovative and state-of-the-art technology - in agreement with University of Edinburgh research's vision.",
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