Notice Information
Notice Title
Provision of Sequencing Equipment and Consumables
Notice Description
Oxford Nanopore Technologies PLC will be providing sequencing equipment and consumables to a number of Trusts for a research programme funded through NHSE. A negotiated procedure without prior publication was used as per regulation 32 to award this contract.
Lot Information
Lot 1
Guys and St Thomas's NHS Foundation Trust (GSTT) has been awarded Funding from NHS England (NHSE) and the Department of Science, Innovation and Technology (the "Funders") for the financial years 2023/24 and 2024/25 as the lead provider for the delivery of the Respiratory Metagenomic Clinical Service Development Programme (the 'Project'), from Oxford Nanopore Technologies PLC.
The Project is a pilot based on patented nanopore based sequencing technology and therefore this contract notice is issued under Regulation 32 (a) of the PCR 2015.
The Project aims to deliver a national respiratory metagenomics (RMg) pilot clinical service with an integrated biosecurity surveillance purpose, as a world-first programme to combine effective infectious disease management with rapid emerging pathogen detection and notification.
Oxford Nanopore sequencing is unique, in that it is the only sequencing technology available on the market that enables direct, real-time analysis of short to ultra-long fragments of DNA/RNA, in fully scalable formats. All Oxford Nanopore sequencing devices use flow cells which contain an array of "nanopores" embedded in an electro-resistant polymer membrane. Oxford Nanopore devices are based around a core sensing unit - a nanopore set in an arrayed sensor chip - used alongside a bespoke Application-Specific Integrated Circuit (ASIC), which controls and measures the experiments. Each nanopore corresponds to its own electrode connected to a channel and sensor chip, which measures the electric current that flows through the nanopore. When a molecule passes through a nanopore, the current is disrupted to produce a characteristic 'squiggle'. The squiggle is then decoded using base-calling algorithms to determine the DNA or RNA sequence in real time. A strand of DNA or RNA is made up of a sequence of different combinations of four nucleotide bases: A, T (or U for RNA), G and C and as each base passes through the nanopore it can be identified through the characteristic disruption it causes to the electrically current in real-time. Advantages of "real-time" sequencing include rapid access to time critical sequencing information (e.g. pathogen identification) and the generation of early sample insights.
* Oxford Nanopore sequencing is unique, in that it is the only sequencing technology available on the market that enables direct, real-time analysis of short to ultra-long fragments of DNA/RNA.
* Direct, real-time nanopore based sequencing and data analysis allows rapid turnaround of results and enabling sample to answer within 6-7hrs.
* Rapid library preparation solutions (from 10 minutes) as well as automatable, high-throughput library preparation that can be performed on various liquid handlers from as little as 3.5 hours for 96 samples.
* Possibility to perform a sequencing run, recover the library from the flow cell, and re-sequence on another flow cell to increase output.
* Real-time sequencing, with integrated compute enabling real-time base calling including epigenetic modifications (5mC and 5hmC, high accuracy base calling model).
* The GridION device can sequence native DNA and RNA from fragment sizes of 20 bp to millions of bases for up to 5 independent MinION Flow Cells.
* Scalable, benchtop and easily portable devices allowing multiple placements and sites to be set up cost efficiently in a decentralised model.
The Project has been jointly funded by NHS England and the Department of Science, Innovation and Technology (DSIT) until March 2025 to support the development of a networked respiratory metagenomics clinical service for acutely unwell patients in ICUs across England. The pilot will generate pathogen sequence and patient metadata with the potential to inform national surveillance systems in partnership with UK Health Security Agency.
As part of the Project, GSTT will disseminate the Funding to the Partner Trust to fund its participation in the Project (the "Work").
The Partner Trusts included in the Work are:
Great Ormand Street Hospital NHS Foundation Trust
University College London Hospitals NHS Foundation Trust / HSL (Pathology supplier to UCLH)
Oxford University Hospitals NHS Foundation Trust
University Hospital Southampton NHS Trust
University Hospitals Birmingham NHS Foundation Trust
Manchester University NHS Foundation Trust
Cambridge University Hospitals NHS Foundation Trust
Newcastle upon Tyne Hospitals NHS Foundation Trust
Guy's and St Thomas' NHS Foundation Trust
Procurement Information
Guys and St Thomas's NHS Foundation Trust (GSTT) has been awarded Funding from NHS England (NHSE) and the Department of Science, Innovation and Technology (the "Funders") for the financial years 2023/24 and 2024/25 as the lead provider for the delivery of the Respiratory Metagenomic Clinical Service Development Programme (the 'Project'), from Oxford Nanopore Technologies PLC.<br/> <br/>The Project is a pilot based on patented nanopore based sequencing technology and therefore this contract notice is issued under Regulation 32 (a) of the PCR 2015.
Notice Details
Publication & Lifecycle
- Open Contracting ID
- ocds-h6vhtk-0453fb
- Publication Source
- Find A Tender Service
- Latest Notice
- https://www.find-tender.service.gov.uk/Notice/012957-2024
- Current Stage
- Award
- All Stages
- Award
Procurement Classification
- Notice Type
- Award Notice
- Procurement Type
- Standard
- Procurement Category
- Goods
- Procurement Method
- Limited
- Procurement Method Details
- Award procedure without prior publication of a call for competition
- Tender Suitability
- Not specified
- Awardee Scale
- Large
Common Procurement Vocabulary (CPV)
- CPV Divisions
33 - Medical equipments, pharmaceuticals and personal care products
-
- CPV Codes
33140000 - Medical consumables
33190000 - Miscellaneous medical devices and products
Notice Value(s)
- Tender Value
- Not specified
- Lots Value
- Not specified
- Awards Value
- Not specified
- Contracts Value
- Not specified
Notice Dates
- Publication Date
- 22 Apr 20241 years ago
- Submission Deadline
- Not specified
- Future Notice Date
- Not specified
- Award Date
- 27 Mar 20241 years ago
- Contract Period
- Not specified - Not specified
- Recurrence
- Not specified
Notice Status
- Tender Status
- Complete
- Lots Status
- Cancelled
- Awards Status
- Active
- Contracts Status
- Active
Buyer & Supplier
Contracting Authority (Buyer)
- Main Buyer
- GUY'S AND ST THOMAS' NHS FOUNDATION TRUST
- Contact Name
- Martin Gibson
- Contact Email
- martin.gibson@gstt.nhs.uk
- Contact Phone
- Not specified
Buyer Location
- Locality
- LONDON
- Postcode
- SE1 9RT
- Post Town
- South East London
- Country
- England
-
- Major Region (ITL 1)
- TLI London
- Basic Region (ITL 2)
- TLI4 Inner London - East
- Small Region (ITL 3)
- TLI44 Lewisham and Southwark
- Delivery Location
- TLI London
-
- Local Authority
- Southwark
- Electoral Ward
- London Bridge & West Bermondsey
- Westminster Constituency
- Bermondsey and Old Southwark
Further Information
Notice URLs
Open Contracting Data Standard (OCDS)
View full OCDS Record for this contracting process
The Open Contracting Data Standard (OCDS) is a framework designed to increase transparency and access to public procurement data in the public sector. It is widely used by governments and organisations worldwide to report on procurement processes and contracts.
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