Notice Information
Notice Title
Knock-out Cell Line Generation
Notice Description
The title of the wider research project is 'Repeat-induced mutagenesis in Huntington's disease' and the overall aim is to understand how expanded CAG/CTG repeats can cause mutagenesis at the Huntington's disease locus.Huntington's disease (HD) is a progressive neurodegenerative disease characterised by involuntary movements, apathy, and cognitive decline. Expansion of CAG/CTG repeats within the HTT gene cause HD. These repeats are genetically unstable, leading to dramatic changes in repeat size, biased towards expansion over an individual's lifetime. Somatic expansion in affected tissues is thought to modify disease presentation and many genes identified in genome-wide association studies play a role in DNA repair and in repeat instability.Repeat instability, defined as gain or loss of repeat units relies on DNA repair processes although the exact mechanisms are still being elucidated. Although several DNA repair components have been implicated in repeat instability, how they work together and how potential sequence context may influence the process is unclear.Part of this project involves investigating the effects of genes associated with DNA repair on repeat instability. 10 different genes of interest have been identified and to investigate their effect on repeat instability, these genes need to be knocked-out in our custom HEK293 cell line.The requirement is for separate knock-out of 10 genes in an immortalised cell line, GFP(CAG)101, which is HEK293-derived. Vincent Dion et al will provide the original cell line as starting material. This material will be mycoplasma tested before being sent. To express interest, please use the following link and join the Tender Project via the tendering portal.https://in-tendhost.co.uk/cardiffuniversity/aspx/Home(WA Ref:138089)
Notice Details
Publication & Lifecycle
- Open Contracting ID
- ocds-kuma6s-138089
- Publication Source
- Sell2Wales
- Latest Notice
- https://www.sell2wales.gov.wales/search/search_switch.aspx?ID=138089
- Current Stage
- Tender
- All Stages
- Tender
Procurement Classification
- Notice Type
- S2W Notice - Website Invitation to Tender Notice
- Procurement Type
- Standard
- Procurement Category
- Services
- Procurement Method
- Open
- Procurement Method Details
- Not specified
- Tender Suitability
- Not specified
- Awardee Scale
- Not specified
Common Procurement Vocabulary (CPV)
- CPV Divisions
73 - Research and development services and related consultancy services
-
- CPV Codes
73000000 - Research and development services and related consultancy services
73100000 - Research and experimental development services
73110000 - Research services
73111000 - Research laboratory services
73200000 - Research and development consultancy services
Notice Value(s)
- Tender Value
- Not specified
- Lots Value
- Not specified
- Awards Value
- Not specified
- Contracts Value
- Not specified
Notice Dates
- Publication Date
- 17 Jan 20242 years ago
- Submission Deadline
- 31 Jan 2024Expired
- Future Notice Date
- Not specified
- Award Date
- Not specified
- Contract Period
- Not specified - Not specified
- Recurrence
- Not specified
Notice Status
- Tender Status
- Not Specified
- Lots Status
- Not Specified
- Awards Status
- Not Specified
- Contracts Status
- Not Specified
Buyer & Supplier
Contracting Authority (Buyer)
- Main Buyer
- CARDIFF UNIVERSITY
- Contact Name
- Georgia Davies
- Contact Email
- Not specified
- Contact Phone
- +44 2920879648
Buyer Location
- Locality
- CARDIFF
- Postcode
- CF24 0DE
- Post Town
- Cardiff
- Country
- Wales
-
- Major Region (ITL 1)
- TLL Wales
- Basic Region (ITL 2)
- TLL5 South East Wales
- Small Region (ITL 3)
- TLL52 Cardiff and Vale of Glamorgan
- Delivery Location
- Not specified
-
- Local Authority
- Cardiff
- Electoral Ward
- Adamsdown
- Westminster Constituency
- Cardiff East
Further Information
Open Contracting Data Standard (OCDS)
View full OCDS Record for this contracting process
The Open Contracting Data Standard (OCDS) is a framework designed to increase transparency and access to public procurement data in the public sector. It is widely used by governments and organisations worldwide to report on procurement processes and contracts.
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