Notice Information
Notice Title
2306/JN - Chromatography System for Protein and Nucleic Acid Purification
Notice Description
The Bose Lab works on understanding the function of non-coding RNA: protein complexes, and how they regulate gene expression. The group uses a combination of functional genomics, biochemistry and structural biology to probe the mechanism of protein:RNA complexes. The lab is generously funded by a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society. The group is also associated with a wider cross-faculty and departmental grouping of labs focused on nucleic acids research within the University of Sheffield as part of the Sheffield Institute for Nucleic Acids; the equipment will therefore be of wider interest to a number of groups within the University. Our work studies how non-protein coding RNAs (ncRNAs) interact with and regulate distinct activities in regulatory enzyme complexes that control chromatin accessibility and therefore transcription in mammalian systems. We have previously shown that direct interactions with ncRNAs are a key regulatory factor for these enzymes. The biochemical and structural biology experiments carried out in the group require the formation of diverse protein:nucleic acid complexes, and their subsequent purification to high levels of purity. We also incorporate a variety of fluorophores into our purified samples. As many of these complexes are only weakly associated or transient, accurate sample preparation requires the ability to operate a number of preparation protocols quickly and reproducibly. Importantly, the ability to simultaneously detect the presence of both protein and RNA components in the sample formation reaction would be beneficial to ensure complexes are formed prior to their use in downstream experiments. The University now requires a chromatography system to support the research into this area. In order to purify proteins, RNA and protein:RNA complexes, the system must be capable of a number of distinct protein purification applications, including but not limited to: Affinity chromatography (e.g Ni/Co affinity, GST, Strep-tag), Anion and cation exchange, and size exclusion chromatography. To preserve the activity and integrity of the purified samples, the system will be housed in a climate controlled cold cabinet operated at 4C. The ability to control and monitor the system remotely would be advantageous. This is an Non-EU open exercise. The ITT can be downloaded by registering and expressing your interest on the University's e-tendering system https://in-tendhost.co.uk/sheffield If you have any questions or comments in relation to this tender they must be submitted via the In-tend system, this can be accessed at https://in-tendhost.co.uk/sheffield Completed tenders must be returned through the same e-tendering system. Closing date for receipt of tenders: 2nd September 2019 at 12 noon (UK time).
Notice Details
Publication & Lifecycle
- Open Contracting ID
- ocds-b5fd17-19e536db-f5a4-426b-b2c7-54a1c5721a7a
- Publication Source
- Contracts Finder
- Latest Notice
- https://www.contractsfinder.service.gov.uk/Notice/e177b1c6-54df-4fa4-8cca-cd9a8463a31a
- Current Stage
- Award
- All Stages
- Tender, Award
Procurement Classification
- Notice Type
- Award Notice
- Procurement Type
- Standard
- Procurement Category
- Goods
- Procurement Method
- Open
- Procurement Method Details
- Open procedure (below threshold)
- Tender Suitability
- SME
- Awardee Scale
- Large
Common Procurement Vocabulary (CPV)
- CPV Divisions
38 - Laboratory, optical and precision equipments (excl. glasses)
-
- CPV Codes
38432200 - Chromatographs
Notice Value(s)
- Tender Value
- £65,000 Under £100K
- Lots Value
- Not specified
- Awards Value
- £65,000 Under £100K
- Contracts Value
- Not specified
Notice Dates
- Publication Date
- 14 Oct 20196 years ago
- Submission Deadline
- 2 Sep 2019Expired
- Future Notice Date
- Not specified
- Award Date
- 9 Oct 20196 years ago
- Contract Period
- 20 Oct 2019 - 22 Oct 2019 30 days
- Recurrence
- Not specified
Notice Status
- Tender Status
- Complete
- Lots Status
- Not Specified
- Awards Status
- Active
- Contracts Status
- Not Specified
Buyer & Supplier
Contracting Authority (Buyer)
- Main Buyer
- UNIVERSITY OF SHEFFIELD
- Contact Name
- Available with D3 Tenders Premium →
- Contact Email
- Available with D3 Tenders Premium →
- Contact Phone
- Available with D3 Tenders Premium →
Buyer Location
- Locality
- SHEFFIELD
- Postcode
- S10 2TN
- Post Town
- Sheffield
- Country
- England
-
- Major Region (ITL 1)
- TLE Yorkshire and The Humber
- Basic Region (ITL 2)
- TLE3 South Yorkshire
- Small Region (ITL 3)
- TLE32 Sheffield
- Delivery Location
- TLE Yorkshire and The Humber
-
- Local Authority
- Sheffield
- Electoral Ward
- Broomhill and Sharrow Vale
- Westminster Constituency
- Sheffield Central
Further Information
Notice Documents
-
https://www.contractsfinder.service.gov.uk/Notice/e177b1c6-54df-4fa4-8cca-cd9a8463a31a
14th October 2019 - Awarded contract notice on Contracts Finder -
https://www.contractsfinder.service.gov.uk/Notice/8e070b5f-a638-432e-8b83-d8a7f47e3ee1
1st August 2019 - Opportunity notice on Contracts Finder -
Open Contracting Data Standard (OCDS)
View full OCDS Record for this contracting process
The Open Contracting Data Standard (OCDS) is a framework designed to increase transparency and access to public procurement data in the public sector. It is widely used by governments and organisations worldwide to report on procurement processes and contracts.
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