Award

3464/JN - Galvo-Scanning TIRF Microscope System for Single Molecule Imaging

UNIVERSITY OF SHEFFIELD

This public procurement record has 1 release in its history.

Award

05 Oct 2022 at 12:43

Award Notice
Summary of the contracting process

The University of Sheffield has awarded a contract for a Galvo-Scanning TIRF Microscope System for Single Molecule Imaging to Cairn Research Ltd. The contract is valued at £294,868.87 GBP. The procurement method was selective, calling off from a framework agreement. The tender period ended on September 13, 2022, and the contract period will start on January 2, 2023, and end on January 3, 2023. The procurement stage is in the award phase, and the contract was recently awarded on September 27, 2022.

This tender presents an opportunity for businesses specialising in the goods category, particularly in microscopes. Small and medium-sized enterprises (SMEs) and voluntary, community, and social enterprises (VCSEs) are considered suitable for this procurement. The University of Sheffield, located in Sheffield, England, initiated this tender to support research in understanding molecular mechanisms related to slow axonal transport. Businesses involved in microscopy equipment and related servicing and maintenance could find this opportunity well-suited for growth and collaboration.

Find more tenders on our Open Data Platform.
How relevant is this notice?

D3 Tenders Premium

Win More Public Sector Contracts

AI-powered tender discovery, pipeline management, and market intelligence — everything you need to grow your public sector business.

Start Free Trial Book a Demo
All Features Pricing

Notice Information

Notice Title

3464/JN - Galvo-Scanning TIRF Microscope System for Single Molecule Imaging

Notice Description

This is a contract awarded via mini-competition under Lot 4 (Super Resolution and Enhanced Resolution Microscopes) of the APUC Framework Agreement for: Microscopes and Imaging Equipment including Associated Servicing, Maintenance and Repairs LAB1028 AP The Twelvetrees Lab work on understanding the molecular mechanisms or slow axonal transport so we can develop a deeper understanding of how this process supports neuronal function and longevity. The group uses a combination of biochemistry, cell biology and single molecule methods to probe transport mechanisms, through generous funding from a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society. The lab is based in the Sheffield Institute for Translational Neuroscience and collaborates with many groups in the building. Our work studies how microtubule motor proteins interact differentially with a variety of cargo to regulate distinct rates of transport. Many of our experiments are built around fluorescence microscopy assays; we rely on self labelling enzymes (SNAPf, CLIPf and HaloTag) in combination with their fluorescent ligands (e.g. TMR, 647-SiR, JF549 etc) for single molecule imaging, and also use fluorescent protein markers (EGFP, mTurquoise2, mScarlet-I etc). We use two broad classes of assay system: 1. primary neuronal cultures for live cell imaging and; 2. in vitro motile systems reconstituted from purified proteins. Typical microscopy applications of the lab include, but are not limited to: live-cell imaging of primary neurons over time scales from minutes to hours; single-molecule imaging in live cells; single molecule imaging of in vitro reconstituted motile systems; FRET of single molecules in vitro and populations of molecules within cells; photoablation and activation; super resolution microscopy. The University now requires a microscopy system to support the research in this area. In order to image live neurons and in vitro reconstituted systems, the system must be capable of a number of distinct microscopy applications, including but not limited to: single molecule TIRF microscopy, instantaneous FRAP and TIRF, live-cell imaging, FRET, DNA-PAINT, widefield fluorescence microscopy. To facilitate single molecule imaging in demanding conditions, the system must have an automated focus drift compensation system to maintain z-position. To preserve the activity and integrity of live neurons, the system will be housed in a temperature controlled enclosure that can be operated at a range of temperatures, from room temperature up to 37C. The system must be mounted on an anti-vibration table to minimise environmental vibrations interfering with imaging. Computer control of the system must facilitate both sub second time lapse imaging of single molecules as well as automated time lapse imaging of several points in the sample over many hours.

Notice Details

Publication & Lifecycle

Open Contracting ID
ocds-b5fd17-26251f43-73e5-455d-9819-1785bc2244b2
Publication Source
Contracts Finder
Latest Notice
https://www.contractsfinder.service.gov.uk/Notice/0315308a-cb55-43c0-97d7-45d1eddbd7a8
Current Stage
Award
All Stages
Award

Procurement Classification

Notice Type
Award Notice
Procurement Type
Framework
Procurement Category
Goods
Procurement Method
Selective
Procurement Method Details
Call-off from a framework agreement
Tender Suitability
SME, VCSE
Awardee Scale
SME

Common Procurement Vocabulary (CPV)

CPV Divisions

38 - Laboratory, optical and precision equipments (excl. glasses)

CPV Codes

38510000 - Microscopes

Notice Value(s)

Tender Value
£294,868 £100K-£500K
Lots Value
Not specified
Awards Value
£294,868 £100K-£500K
Contracts Value
Not specified

Notice Dates

Publication Date
5 Oct 20223 years ago
Submission Deadline
13 Sep 2022Expired
Future Notice Date
Not specified
Award Date
26 Sep 20223 years ago
Contract Period
2 Jan 2023 - 3 Jan 2023 30 days
Recurrence
Not specified

Notice Status

Tender Status
Complete
Lots Status
Not Specified
Awards Status
Active
Contracts Status
Not Specified

Buyer & Supplier

Contracting Authority (Buyer)

Main Buyer
UNIVERSITY OF SHEFFIELD
Contact Name
Available with D3 Tenders Premium →
Contact Email
Available with D3 Tenders Premium →
Contact Phone
Available with D3 Tenders Premium →

Buyer Location

Locality
SHEFFIELD
Postcode
S10 2TN
Post Town
Sheffield
Country
England
Major Region (ITL 1)
TLE Yorkshire and The Humber
Basic Region (ITL 2)
TLE3 South Yorkshire
Small Region (ITL 3)
TLE32 Sheffield
Delivery Location
TLE Yorkshire and The Humber
Local Authority
Sheffield
Electoral Ward
Broomhill and Sharrow Vale
Westminster Constituency
Sheffield Central

Supplier Information

Number of Suppliers
1
Supplier Name

CAIRN RESEARCH

Further Information

Notice Documents

Open Contracting Data Standard (OCDS)

View full OCDS Record for this contracting process

Download

The Open Contracting Data Standard (OCDS) is a framework designed to increase transparency and access to public procurement data in the public sector. It is widely used by governments and organisations worldwide to report on procurement processes and contracts. 

{
    "tag": [
        "compiled"
    ],
    "id": "ocds-b5fd17-26251f43-73e5-455d-9819-1785bc2244b2-2022-10-05T13:43:39+01:00",
    "date": "2022-10-05T13:43:39+01:00",
    "ocid": "ocds-b5fd17-26251f43-73e5-455d-9819-1785bc2244b2",
    "language": "en",
    "initiationType": "tender",
    "tender": {
        "id": "3464/JN",
        "title": "3464/JN - Galvo-Scanning TIRF Microscope System for Single Molecule Imaging",
        "description": "This is a contract awarded via mini-competition under Lot 4 (Super Resolution and Enhanced Resolution Microscopes) of the APUC Framework Agreement for: Microscopes and Imaging Equipment including Associated Servicing, Maintenance and Repairs LAB1028 AP The Twelvetrees Lab work on understanding the molecular mechanisms or slow axonal transport so we can develop a deeper understanding of how this process supports neuronal function and longevity. The group uses a combination of biochemistry, cell biology and single molecule methods to probe transport mechanisms, through generous funding from a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society. The lab is based in the Sheffield Institute for Translational Neuroscience and collaborates with many groups in the building. Our work studies how microtubule motor proteins interact differentially with a variety of cargo to regulate distinct rates of transport. Many of our experiments are built around fluorescence microscopy assays; we rely on self labelling enzymes (SNAPf, CLIPf and HaloTag) in combination with their fluorescent ligands (e.g. TMR, 647-SiR, JF549 etc) for single molecule imaging, and also use fluorescent protein markers (EGFP, mTurquoise2, mScarlet-I etc). We use two broad classes of assay system: 1. primary neuronal cultures for live cell imaging and; 2. in vitro motile systems reconstituted from purified proteins. Typical microscopy applications of the lab include, but are not limited to: live-cell imaging of primary neurons over time scales from minutes to hours; single-molecule imaging in live cells; single molecule imaging of in vitro reconstituted motile systems; FRET of single molecules in vitro and populations of molecules within cells; photoablation and activation; super resolution microscopy. The University now requires a microscopy system to support the research in this area. In order to image live neurons and in vitro reconstituted systems, the system must be capable of a number of distinct microscopy applications, including but not limited to: single molecule TIRF microscopy, instantaneous FRAP and TIRF, live-cell imaging, FRET, DNA-PAINT, widefield fluorescence microscopy. To facilitate single molecule imaging in demanding conditions, the system must have an automated focus drift compensation system to maintain z-position. To preserve the activity and integrity of live neurons, the system will be housed in a temperature controlled enclosure that can be operated at a range of temperatures, from room temperature up to 37C. The system must be mounted on an anti-vibration table to minimise environmental vibrations interfering with imaging. Computer control of the system must facilitate both sub second time lapse imaging of single molecules as well as automated time lapse imaging of several points in the sample over many hours.",
        "status": "complete",
        "classification": {
            "scheme": "CPV",
            "id": "38510000",
            "description": "Microscopes"
        },
        "items": [
            {
                "id": "1",
                "deliveryAddresses": [
                    {
                        "region": "Yorkshire and the Humber",
                        "countryName": "United Kingdom"
                    }
                ]
            }
        ],
        "value": {
            "amount": 294868.87,
            "currency": "GBP"
        },
        "procurementMethod": "selective",
        "procurementMethodDetails": "Call-off from a framework agreement",
        "tenderPeriod": {
            "endDate": "2022-09-13T12:00:00+01:00"
        },
        "contractPeriod": {
            "startDate": "2023-01-02T00:00:00Z",
            "endDate": "2023-01-03T23:59:59Z"
        },
        "suitability": {
            "sme": true,
            "vcse": true
        },
        "mainProcurementCategory": "goods"
    },
    "parties": [
        {
            "id": "GB-SRS-sid4gov.cabinetoffice.gov.uk/JYFy743W",
            "name": "UNIVERSITY OF SHEFFIELD",
            "identifier": {
                "legalName": "UNIVERSITY OF SHEFFIELD",
                "scheme": "GB-SRS",
                "id": "sid4gov.cabinetoffice.gov.uk/JYFy743W"
            },
            "address": {
                "streetAddress": "Western Bank",
                "locality": "SHEFFIELD",
                "postalCode": "S102TN",
                "countryName": "England"
            },
            "contactPoint": {
                "name": "James Noble",
                "email": "james.noble@sheffield.ac.uk"
            },
            "roles": [
                "buyer"
            ]
        },
        {
            "id": "GB-COH-01881330",
            "name": "Cairn Research Ltd",
            "identifier": {
                "legalName": "Cairn Research Ltd",
                "scheme": "GB-COH",
                "id": "01881330"
            },
            "address": {
                "streetAddress": "Graveney Road Faversham ME13 8UP"
            },
            "details": {
                "scale": "sme",
                "vcse": false
            },
            "roles": [
                "supplier"
            ]
        }
    ],
    "buyer": {
        "id": "GB-SRS-sid4gov.cabinetoffice.gov.uk/JYFy743W",
        "name": "UNIVERSITY OF SHEFFIELD"
    },
    "awards": [
        {
            "id": "ocds-b5fd17-26251f43-73e5-455d-9819-1785bc2244b2-1",
            "status": "active",
            "date": "2022-09-27T00:00:00+01:00",
            "datePublished": "2022-10-05T13:43:39+01:00",
            "value": {
                "amount": 294868.87,
                "currency": "GBP"
            },
            "suppliers": [
                {
                    "id": "GB-COH-01881330",
                    "name": "Cairn Research Ltd"
                }
            ],
            "contractPeriod": {
                "startDate": "2023-01-02T00:00:00Z",
                "endDate": "2023-01-03T23:59:59Z"
            },
            "documents": [
                {
                    "id": "1",
                    "documentType": "awardNotice",
                    "description": "Awarded contract notice on Contracts Finder",
                    "url": "https://www.contractsfinder.service.gov.uk/Notice/0315308a-cb55-43c0-97d7-45d1eddbd7a8",
                    "datePublished": "2022-10-05T13:43:39+01:00",
                    "format": "text/html",
                    "language": "en"
                }
            ]
        }
    ]
}