Notice Information
Notice Title
Integrated bioreactor platform for rapid scale-up and translation
Notice Description
This tender is being run on behalf of Dr James Winterburn, Reader in Chemical Engineering. Dr Winterburn led a successful BBSRC ALERT21 equipment bid "Integrated bioreactor platform for rapid scale-up and translation", which will provide significant bioreactor capacity for microbial fermentation process development, scale up and translation for a range of bio-based chemicals. The exploitation of bio-based production routes requires a thorough understanding of production strain performance and an ability to rapidly and effectively scale processes from millilitres to tens of litres. The bioreactor platform is intended to provide understanding of how process conditions at different volumes and variability across process parameters (e.g., mixing speeds, dissolved O2, pH), affect host cell performance. The integrated bioreactor platform will bridge across three scales, outlined below, and allow for rapid process development and ultimately support research translation. Small-scale: Parallel bioreactor system (500 mL, 6 vessels) for rapid parallel process development, strain testing and parameter optimization for microbial fermentations in batch, fed-batch and continuous cultivation, with off gas analysis capability Mid-scale (3L bioreactor system, four vessels): For initial scale up and process development work (e.g., confirmation of feeding profiles, metabolic profiling) and preliminary process analysis (including; yield, productivity, final titre) with off gas analysis capability. Also serves as the seed train for inoculum preparation for scale up to 40L. Large-scale feasibility (40L SIP bioreactor): To enable in-house demonstration of process technical feasibility, production of sufficient quantities of material for application testing and benchmarking and provision of data for robust techno-economic analysis which can be used as the basis for commercialisation, also with off gas analysis capability.
Lot Information
Lot 1
This tender is being run on behalf of Dr James Winterburn, Reader in Chemical Engineering. Dr Winterburn led a successful BBSRC ALERT21 equipment bid "Integrated bioreactor platform for rapid scale-up and translation", which will provide significant bioreactor capacity for microbial fermentation process development, scale up and translation for a range of bio-based chemicals. The exploitation of bio-based production routes requires a thorough understanding of production strain performance and an ability to rapidly and effectively scale processes from millilitres to tens of litres. The bioreactor platform is intended to provide understanding of how process conditions at different volumes and variability across process parameters (e.g., mixing speeds, dissolved O2, pH), affect host cell performance. The integrated bioreactor platform will bridge across three scales, outlined below, and allow for rapid process development and ultimately support research translation. Small-scale: Parallel bioreactor system (500 mL, 6 vessels) for rapid parallel process development, strain testing and parameter optimization for microbial fermentations in batch, fed-batch and continuous cultivation, with off gas analysis capability Mid-scale (3L bioreactor system, four vessels): For initial scale up and process development work (e.g., confirmation of feeding profiles, metabolic profiling) and preliminary process analysis (including; yield, productivity, final titre) with off gas analysis capability. Also serves as the seed train for inoculum preparation for scale up to 40L. Large-scale feasibility (40L SIP bioreactor): To enable in-house demonstration of process technical feasibility, production of sufficient quantities of material for application testing and benchmarking and provision of data for robust techno-economic analysis which can be used as the basis for commercialisation, also with off gas analysis capability.
Notice Details
Publication & Lifecycle
- Open Contracting ID
- ocds-h6vhtk-03c372
- Publication Source
- Find A Tender Service
- Latest Notice
- https://www.find-tender.service.gov.uk/Notice/011610-2023
- Current Stage
- Tender
- All Stages
- Tender
Procurement Classification
- Notice Type
- Tender Notice
- Procurement Type
- Standard
- Procurement Category
- Goods
- Procurement Method
- Open
- Procurement Method Details
- Open procedure
- Tender Suitability
- Not specified
- Awardee Scale
- Not specified
Common Procurement Vocabulary (CPV)
- CPV Divisions
38 - Laboratory, optical and precision equipments (excl. glasses)
42 - Industrial machinery
-
- CPV Codes
38000000 - Laboratory, optical and precision equipments (excl. glasses)
42993000 - Chemical industry machinery
Notice Value(s)
- Tender Value
- Not specified
- Lots Value
- Not specified
- Awards Value
- Not specified
- Contracts Value
- Not specified
Notice Dates
- Publication Date
- 24 Apr 20232 years ago
- Submission Deadline
- 25 May 2023Expired
- Future Notice Date
- Not specified
- Award Date
- Not specified
- Contract Period
- 7 Jun 2023 - 14 Feb 2024 6-12 months
- Recurrence
- Not specified
Notice Status
- Tender Status
- Active
- Lots Status
- Active
- Awards Status
- Not Specified
- Contracts Status
- Not Specified
Buyer & Supplier
Contracting Authority (Buyer)
- Main Buyer
- UNIVERSITY OF MANCHESTER
- Contact Name
- Paul Carter
- Contact Email
- paul.carter-2@manchester.ac.uk
- Contact Phone
- Not specified
Buyer Location
- Locality
- MANCHESTER
- Postcode
- M13 9PL
- Post Town
- Manchester
- Country
- England
-
- Major Region (ITL 1)
- TLD North West (England)
- Basic Region (ITL 2)
- TLD3 Greater Manchester
- Small Region (ITL 3)
- TLD33 Manchester
- Delivery Location
- TLD3 Greater Manchester
-
- Local Authority
- Manchester
- Electoral Ward
- Hulme
- Westminster Constituency
- Manchester Rusholme
Further Information
Open Contracting Data Standard (OCDS)
View full OCDS Record for this contracting process
The Open Contracting Data Standard (OCDS) is a framework designed to increase transparency and access to public procurement data in the public sector. It is widely used by governments and organisations worldwide to report on procurement processes and contracts.
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